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• W2027173635 abstract "Insulin-like growth factor-I (IGF-I) has been shown to stimulate biosynthesis of progesterone and other differentiated functions of granulosa cells. The presence of the IGF-I receptor messenger RNA and IGF-I receptor as well as the role of IGF-I in the amplification of gonadotropin action in luteinized rat ovarian cells were assessed in the present study. Rat ovarian luteal tissue were obtained on day 6 of pseudopregnancy. After collagenase dispersion, luteal cells were cultured with or without IGF-I for 72 h in a serum-free medium in the absence or presence of human CG (100 ng/ml), 8-bromo-cAMP (1 mM), and 25-OH cholesterol (30 ng/ml). IGF-I alone increased (P < 0.01) progesterone secretion 47% over controls. When combined with hCG the increase in progesterone secretion was enhanced 6-fold (P < 0.001) over controls. The effects of 8 bromo-cAMP on progesterone secretion also was amplified (P < 0.001) when IGF-I was present in the medium. When 25-OH cholesterol, a diffusable substrate for steroidogenesis, was included in the incubation medium along with IGF-I, progesterone secretion was enhanced significantly (P < 0.01) over controls and either treatment alone. Binding studies performed with ovarian luteal cell membranes in the ovary revealed a dissociation constant of 0.94 nM for the IGF-I receptor. Autoradiograms from affinity labeling studies revealed a band corresponding to 132Kd which is characteristic for the α-subunit of the type I IGF receptor. Northern blot analysis showed the presence of a major transcript at approximately 11 kilobases, which agrees with the size of the IGF-I receptor messenger RNA. In conclusion, we provide evidence for the fact that IGF-I regulates differentiated functions of the corpus luteum through interaction with specific high affinity IGF-I receptors. (Endocrinology129: 1340–1346, 1991)" @default.
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• W2027173635 title "Studies on Rat Luteal Cell Response to Insulin-Like Growth Factor I (IGF-I): Identification of a Specific Cell Membrane Receptor for IGF-I in the Luteinized Rat Ovary^*" @default.
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• W2027173635 doi "https://doi.org/10.1210/endo-129-3-1340" @default.
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