Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027173882> ?p ?o ?g. }
- W2027173882 endingPage "282" @default.
- W2027173882 startingPage "276" @default.
- W2027173882 abstract "Elevated blood histamine plays a role in the pathogenesis of atherosclerosis. Calcium signaling mediates histamine action in endothelial cells. Selenium (Se) is a dietary essential trace element for humans. Se compounds in different oxidation states were found to exhibit an opposing effect on the histamine-induced calcium signaling in the ECV304 cell line. When Se in the form of sodium selenite was added in the cell culture, the reactivity of the histamine H1-receptor was increased as reported in our previous paper. We here show that as a culture supplement, sodium selenite enhanced the activity of selenoprotein thioredoxin reductase (TrxR) and the calcium response to histamine stimulation, which were reversed by treating the cells with gold thioglucose, a nucleophilic drug that selectively modifies thiolate/selenolate groups. Sodium selenite most likely caused a reductive shift in the thiol/disulfide redox balance through increasing TrxR activity. In contrast, when the cells were treated with Se in the form of ebselen, a thiol oxidant with peroxidase-like activity, histamine-induced calcium release and calcium entry were significantly suppressed. This effect appeared related to the thiol-directed modification rather than the peroxidase-like activity of ebselen, because this inhibitory effect was not replicated by increasing cellular peroxidase activity. Thus, the opposing effects of sodium selenite and ebselen on histamine-induced calcium signaling are achieved, at least in part, through their opposite actions in modulating the thiol/disulfide redox state." @default.
- W2027173882 created "2016-06-24" @default.
- W2027173882 creator A5025633795 @default.
- W2027173882 creator A5051144059 @default.
- W2027173882 date "2010-01-01" @default.
- W2027173882 modified "2023-10-18" @default.
- W2027173882 title "Opposing regulation of histamine-induced calcium signaling by sodium selenite and ebselen via alterations of thiol redox status" @default.
- W2027173882 cites W1539041260 @default.
- W2027173882 cites W1550989824 @default.
- W2027173882 cites W1555938743 @default.
- W2027173882 cites W1747918402 @default.
- W2027173882 cites W1958244357 @default.
- W2027173882 cites W1967456795 @default.
- W2027173882 cites W1972453231 @default.
- W2027173882 cites W1973123943 @default.
- W2027173882 cites W1984201510 @default.
- W2027173882 cites W1986584051 @default.
- W2027173882 cites W1990484506 @default.
- W2027173882 cites W1999501523 @default.
- W2027173882 cites W2008820074 @default.
- W2027173882 cites W2011836829 @default.
- W2027173882 cites W2019018307 @default.
- W2027173882 cites W2024102949 @default.
- W2027173882 cites W2027561572 @default.
- W2027173882 cites W2036180325 @default.
- W2027173882 cites W2040504184 @default.
- W2027173882 cites W2041747892 @default.
- W2027173882 cites W2051011620 @default.
- W2027173882 cites W2063447619 @default.
- W2027173882 cites W2068545219 @default.
- W2027173882 cites W2072320720 @default.
- W2027173882 cites W2075774738 @default.
- W2027173882 cites W2076826699 @default.
- W2027173882 cites W2079010386 @default.
- W2027173882 cites W2079912175 @default.
- W2027173882 cites W2083643135 @default.
- W2027173882 cites W2103650142 @default.
- W2027173882 cites W2113983191 @default.
- W2027173882 cites W2114030086 @default.
- W2027173882 cites W2115950496 @default.
- W2027173882 cites W2126335528 @default.
- W2027173882 cites W2129499825 @default.
- W2027173882 cites W2140676951 @default.
- W2027173882 cites W2141321721 @default.
- W2027173882 cites W2152076661 @default.
- W2027173882 cites W2156588473 @default.
- W2027173882 cites W2163233470 @default.
- W2027173882 cites W2172938682 @default.
- W2027173882 cites W2262493202 @default.
- W2027173882 cites W2301092763 @default.
- W2027173882 cites W287525851 @default.
- W2027173882 cites W312187524 @default.
- W2027173882 cites W4240395987 @default.
- W2027173882 cites W4247896860 @default.
- W2027173882 cites W72697230 @default.
- W2027173882 doi "https://doi.org/10.1016/j.ejphar.2009.09.034" @default.
- W2027173882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19782065" @default.
- W2027173882 hasPublicationYear "2010" @default.
- W2027173882 type Work @default.
- W2027173882 sameAs 2027173882 @default.
- W2027173882 citedByCount "4" @default.
- W2027173882 countsByYear W20271738822012 @default.
- W2027173882 countsByYear W20271738822013 @default.
- W2027173882 countsByYear W20271738822019 @default.
- W2027173882 crossrefType "journal-article" @default.
- W2027173882 hasAuthorship W2027173882A5025633795 @default.
- W2027173882 hasAuthorship W2027173882A5051144059 @default.
- W2027173882 hasConcept C1122143 @default.
- W2027173882 hasConcept C134018914 @default.
- W2027173882 hasConcept C178790620 @default.
- W2027173882 hasConcept C185592680 @default.
- W2027173882 hasConcept C2775838275 @default.
- W2027173882 hasConcept C2776151105 @default.
- W2027173882 hasConcept C2778760513 @default.
- W2027173882 hasConcept C2779138974 @default.
- W2027173882 hasConcept C2781324293 @default.
- W2027173882 hasConcept C519063684 @default.
- W2027173882 hasConcept C55493867 @default.
- W2027173882 hasConcept C86803240 @default.
- W2027173882 hasConceptScore W2027173882C1122143 @default.
- W2027173882 hasConceptScore W2027173882C134018914 @default.
- W2027173882 hasConceptScore W2027173882C178790620 @default.
- W2027173882 hasConceptScore W2027173882C185592680 @default.
- W2027173882 hasConceptScore W2027173882C2775838275 @default.
- W2027173882 hasConceptScore W2027173882C2776151105 @default.
- W2027173882 hasConceptScore W2027173882C2778760513 @default.
- W2027173882 hasConceptScore W2027173882C2779138974 @default.
- W2027173882 hasConceptScore W2027173882C2781324293 @default.
- W2027173882 hasConceptScore W2027173882C519063684 @default.
- W2027173882 hasConceptScore W2027173882C55493867 @default.
- W2027173882 hasConceptScore W2027173882C86803240 @default.
- W2027173882 hasIssue "2-3" @default.
- W2027173882 hasLocation W20271738821 @default.
- W2027173882 hasLocation W20271738822 @default.
- W2027173882 hasOpenAccess W2027173882 @default.
- W2027173882 hasPrimaryLocation W20271738821 @default.
- W2027173882 hasRelatedWork W1836097862 @default.
- W2027173882 hasRelatedWork W1986669241 @default.