Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027174276> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2027174276 endingPage "S98" @default.
- W2027174276 startingPage "S98" @default.
- W2027174276 abstract "Release of acetylcholine (ACh) from preganglionic nerve terminals requires calcium entry through voltage-gated calcium channels. The calcium channel subtype required for ACh release varies depending on the particular ganglionic synapse. I have investigated the functional role of calcium channels in transmitter release from parasympathetic and sympathetic preganglionic terminals in pelvic and celiac ganglia of female mice. Single electrode voltage clamp was used to measure EPSC amplitude in the absence and presence of selective calcium channel antagonists. In pelvic ganglia ω- conotoxin GVIA, a selective N-type calcium channel antagonist, reduced the amplitude of EPSCs evoked by pelvic nerve stimulation by 46 ± 5% (n = 8, P = 0.015). In contrast, in the celiac ganglion, ω- conotoxin GVIA had no effect on the amplitude of EPSCs evoked by splanchnic nerve stimulation (P = 0.09, n = 7). EPSCs in both pelvic and celiac ganglia were resistant to the P-type calcium channel antagonist agatoxin (50 nM, n = 5 for both ganglia) and the R-type calcium channel antagonist SNX482 (100 nM, n = 4 for both ganglia). These results indicate that in female mice, release of ACh in sympathetic pathways to prevertebral ganglia does not require calcium entry from N-type calcium channels. However, release of ACh from sacral parasympathetic preganglionic neurons requires calcium entry from both N-type and toxin-resistant calcium channels." @default.
- W2027174276 created "2016-06-24" @default.
- W2027174276 creator A5037442203 @default.
- W2027174276 creator A5059703938 @default.
- W2027174276 creator A5075296054 @default.
- W2027174276 date "1998-01-01" @default.
- W2027174276 modified "2023-10-18" @default.
- W2027174276 title "Calcium dependency of ω-AGA IVA effects on large and small excitatory junctional potentials and ultrastructures of nerve terminals producing these potentials" @default.
- W2027174276 doi "https://doi.org/10.1016/s0168-0102(98)81924-x" @default.
- W2027174276 hasPublicationYear "1998" @default.
- W2027174276 type Work @default.
- W2027174276 sameAs 2027174276 @default.
- W2027174276 citedByCount "0" @default.
- W2027174276 crossrefType "journal-article" @default.
- W2027174276 hasAuthorship W2027174276A5037442203 @default.
- W2027174276 hasAuthorship W2027174276A5059703938 @default.
- W2027174276 hasAuthorship W2027174276A5075296054 @default.
- W2027174276 hasConcept C105702510 @default.
- W2027174276 hasConcept C112592302 @default.
- W2027174276 hasConcept C126322002 @default.
- W2027174276 hasConcept C134018914 @default.
- W2027174276 hasConcept C166832727 @default.
- W2027174276 hasConcept C169760540 @default.
- W2027174276 hasConcept C17077164 @default.
- W2027174276 hasConcept C178790620 @default.
- W2027174276 hasConcept C185592680 @default.
- W2027174276 hasConcept C18699975 @default.
- W2027174276 hasConcept C24998067 @default.
- W2027174276 hasConcept C30979828 @default.
- W2027174276 hasConcept C519063684 @default.
- W2027174276 hasConcept C71924100 @default.
- W2027174276 hasConcept C85520022 @default.
- W2027174276 hasConcept C86803240 @default.
- W2027174276 hasConcept C92645518 @default.
- W2027174276 hasConceptScore W2027174276C105702510 @default.
- W2027174276 hasConceptScore W2027174276C112592302 @default.
- W2027174276 hasConceptScore W2027174276C126322002 @default.
- W2027174276 hasConceptScore W2027174276C134018914 @default.
- W2027174276 hasConceptScore W2027174276C166832727 @default.
- W2027174276 hasConceptScore W2027174276C169760540 @default.
- W2027174276 hasConceptScore W2027174276C17077164 @default.
- W2027174276 hasConceptScore W2027174276C178790620 @default.
- W2027174276 hasConceptScore W2027174276C185592680 @default.
- W2027174276 hasConceptScore W2027174276C18699975 @default.
- W2027174276 hasConceptScore W2027174276C24998067 @default.
- W2027174276 hasConceptScore W2027174276C30979828 @default.
- W2027174276 hasConceptScore W2027174276C519063684 @default.
- W2027174276 hasConceptScore W2027174276C71924100 @default.
- W2027174276 hasConceptScore W2027174276C85520022 @default.
- W2027174276 hasConceptScore W2027174276C86803240 @default.
- W2027174276 hasConceptScore W2027174276C92645518 @default.
- W2027174276 hasLocation W20271742761 @default.
- W2027174276 hasOpenAccess W2027174276 @default.
- W2027174276 hasPrimaryLocation W20271742761 @default.
- W2027174276 hasRelatedWork W1639584526 @default.
- W2027174276 hasRelatedWork W1678527168 @default.
- W2027174276 hasRelatedWork W2031844916 @default.
- W2027174276 hasRelatedWork W2045160111 @default.
- W2027174276 hasRelatedWork W2046962705 @default.
- W2027174276 hasRelatedWork W2047213097 @default.
- W2027174276 hasRelatedWork W2058619297 @default.
- W2027174276 hasRelatedWork W2091430943 @default.
- W2027174276 hasRelatedWork W2394712588 @default.
- W2027174276 hasRelatedWork W994978426 @default.
- W2027174276 hasVolume "31" @default.
- W2027174276 isParatext "false" @default.
- W2027174276 isRetracted "false" @default.
- W2027174276 magId "2027174276" @default.
- W2027174276 workType "article" @default.