Matches in SemOpenAlex for { <https://semopenalex.org/work/W202718393> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W202718393 abstract "DNA damage can lead not only to mutations and chromosome abnormalities, but also to epigenetic effects on gene expression. It is therefore very important to consider the possible effects of oxidative damage to DNA on epigenetic controls. In somatic cells of higher organisms there are two heritable systems which exist side by side (Holliday, 1990). Classical genetics is concerned with the inheritance of differences in DNA sequences. These differences are transmitted through mitosis and meiosis and can only be reversed or changed by rare mutations. Epigenetics is the study of the changes in gene activity during development. The epigenetic basis for gene expression can be stably inherited through mitosis, since specialised differentiated cells which divide maintain their phenotype. However, there can also be instability, since stem line cells can divide both to form cells which will later differentiate, and also cells which retain their stem cell function. Whereas classical genetic inheritance is concerned with individual cell lineages, epigenetic changes during development commonly occur in groups of cells sometimes called “polyclones” (Crick and Lawrence, 1975). Such changes may be strongly influenced by external effectors (morphogens, hormones, growth factors, or other diffusible agents), whereas the genetic information embodied in DNA sequences is not changed by external influences. Epigenetic changes are commonly reversed in each generation, for example, the inactive X chromosome in female mammals is reactivated before the gametes are produced. The process of genomic imprinting depends on the addition of information to DNA which is different in male and female gametes. Imprinting can also be regarded as an epigenetic mechanism, which can be reversed in each generation." @default.
- W202718393 created "2016-06-24" @default.
- W202718393 creator A5029733414 @default.
- W202718393 date "1995-01-01" @default.
- W202718393 modified "2023-10-07" @default.
- W202718393 title "DNA damage and epigenetic mechanisms of aging" @default.
- W202718393 cites W1964414968 @default.
- W202718393 cites W1967742830 @default.
- W202718393 cites W1973985479 @default.
- W202718393 cites W1978489126 @default.
- W202718393 cites W1986223011 @default.
- W202718393 cites W1987793414 @default.
- W202718393 cites W2002875180 @default.
- W202718393 cites W2006488092 @default.
- W202718393 cites W2017499821 @default.
- W202718393 cites W2017595171 @default.
- W202718393 cites W2042369211 @default.
- W202718393 cites W2046359892 @default.
- W202718393 cites W2046753233 @default.
- W202718393 cites W2053299174 @default.
- W202718393 cites W2069713835 @default.
- W202718393 cites W2073215713 @default.
- W202718393 cites W2074245751 @default.
- W202718393 cites W2100475900 @default.
- W202718393 cites W2136219225 @default.
- W202718393 cites W4235777292 @default.
- W202718393 doi "https://doi.org/10.1007/978-3-0348-7337-6_8" @default.
- W202718393 hasPublicationYear "1995" @default.
- W202718393 type Work @default.
- W202718393 sameAs 202718393 @default.
- W202718393 citedByCount "0" @default.
- W202718393 crossrefType "book-chapter" @default.
- W202718393 hasAuthorship W202718393A5029733414 @default.
- W202718393 hasConcept C104317684 @default.
- W202718393 hasConcept C134305767 @default.
- W202718393 hasConcept C150194340 @default.
- W202718393 hasConcept C190727270 @default.
- W202718393 hasConcept C201492766 @default.
- W202718393 hasConcept C41091548 @default.
- W202718393 hasConcept C54355233 @default.
- W202718393 hasConcept C86803240 @default.
- W202718393 hasConcept C93304396 @default.
- W202718393 hasConcept C95444343 @default.
- W202718393 hasConceptScore W202718393C104317684 @default.
- W202718393 hasConceptScore W202718393C134305767 @default.
- W202718393 hasConceptScore W202718393C150194340 @default.
- W202718393 hasConceptScore W202718393C190727270 @default.
- W202718393 hasConceptScore W202718393C201492766 @default.
- W202718393 hasConceptScore W202718393C41091548 @default.
- W202718393 hasConceptScore W202718393C54355233 @default.
- W202718393 hasConceptScore W202718393C86803240 @default.
- W202718393 hasConceptScore W202718393C93304396 @default.
- W202718393 hasConceptScore W202718393C95444343 @default.
- W202718393 hasLocation W2027183931 @default.
- W202718393 hasOpenAccess W202718393 @default.
- W202718393 hasPrimaryLocation W2027183931 @default.
- W202718393 hasRelatedWork W1534073590 @default.
- W202718393 hasRelatedWork W1948870174 @default.
- W202718393 hasRelatedWork W1967064280 @default.
- W202718393 hasRelatedWork W1967633322 @default.
- W202718393 hasRelatedWork W1974597443 @default.
- W202718393 hasRelatedWork W2058470179 @default.
- W202718393 hasRelatedWork W2118837234 @default.
- W202718393 hasRelatedWork W2241082605 @default.
- W202718393 hasRelatedWork W2327525223 @default.
- W202718393 hasRelatedWork W2503515660 @default.
- W202718393 hasRelatedWork W2505197619 @default.
- W202718393 hasRelatedWork W2584928363 @default.
- W202718393 hasRelatedWork W2741267999 @default.
- W202718393 hasRelatedWork W2914136442 @default.
- W202718393 hasRelatedWork W2942197998 @default.
- W202718393 hasRelatedWork W3047601451 @default.
- W202718393 hasRelatedWork W3114765785 @default.
- W202718393 hasRelatedWork W3192891376 @default.
- W202718393 hasRelatedWork W871827426 @default.
- W202718393 hasRelatedWork W2091161816 @default.
- W202718393 isParatext "false" @default.
- W202718393 isRetracted "false" @default.
- W202718393 magId "202718393" @default.
- W202718393 workType "book-chapter" @default.