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- W2027215771 abstract "A new theoretical model for the growth of saccular cerebral aneurysms is proposed by extending the recent constitutive framework of Kroon and Holzapfel [2007a. A model for saccular cerebral aneurysm growth by collagen fibre remodelling. J. Theor. Biol. 247, 775-787]. The continuous turnover of collagen is taken to be the driving mechanism in aneurysmal growth. The collagen production rate depends on the magnitude of the cyclic deformation of fibroblasts, caused by the pulsating blood pressure during the cardiac cycle. The volume density of fibroblasts in the aneurysmal tissue is taken to be constant throughout the growth process. The growth model is assessed by considering the inflation of an axisymmetric membranous piece of aneurysmal tissue, with material characteristics representative of a cerebral aneurysm. The diastolic and systolic states of the aneurysm are computed, together with its load-free state. It turns out that the value of collagen pre-stretch, that determines growth speed and stability of the aneurysm, is of pivotal importance. The model is able to predict aneurysms with typical berry-like shapes observed clinically, and the predicted wall stresses correlate well with the experimentally obtained ultimate stresses of this type of tissue. The model predicts that aneurysms should fail when reaching a size of about 1.2-3.6mm, which is smaller than what has been clinically observed. With some refinements, the model may, however, be used to predict future growth of diagnosed aneurysms." @default.
- W2027215771 created "2016-06-24" @default.
- W2027215771 creator A5006819872 @default.
- W2027215771 creator A5063835505 @default.
- W2027215771 date "2009-03-01" @default.
- W2027215771 modified "2023-10-01" @default.
- W2027215771 title "A theoretical model for fibroblast-controlled growth of saccular cerebral aneurysms" @default.
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- W2027215771 doi "https://doi.org/10.1016/j.jtbi.2008.10.021" @default.
- W2027215771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19027028" @default.
- W2027215771 hasPublicationYear "2009" @default.
- W2027215771 type Work @default.