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• W2027220003 abstract "Nuclear inhibitor of protein phosphatase‐1 (NIPP‐1) is one of two major regulatory subunits of protein phosphatase‐1 in mammalian nuclei. We report here the cloning and structural characterization of the human NIPP‐1 genes, designated PPP1R8P and PPP1R8 in human gene nomenclature. PPP1R8P (1.2 kb) is a processed pseudogene and was localized by in situ hybridization to chromosome 1p33–32. PPP1R8 is an authentic NIPP‐1 gene and was localized to chromosome 1p35. PPP1R8 (25.2 kb) is composed of seven exons and encodes four different transcripts, as determined from cDNA library screening, reverse transcriptase‐PCR (RT‐PCR) and/or EST (expressed sequence tag) database search analysis. NIPP‐1α mRNA represents the major transcript in human tissues and various cell lines, and encodes a polypeptide of 351 residues that only differs from the previously cloned calf thymus NIPP‐1 by a single residue. The other transcripts, termed NIPP‐1β, γ and δ, are generated by alternative 5′‐splice site usage, by exon skipping and/or by alternative polyadenylation. The NIPP‐1β/δ and NIPP‐1γ mRNAs are expected to encode fragments of NIPP‐1α that differ from the latter by the absence of the first 142 and 224 residues, respectively. NIPP‐1γ corresponds to ‘activator of RNA decay‐1’ (Ard‐1) which, unlike NIPP‐1α, displays in vitro and endoribonuclease activity and lacks an RVXF consensus motif for interaction with protein phosphatase‐1. While the NIPP‐1α/β/δ‐transcripts were found to be present in various human tissues, the NIPP‐1γ transcript could only be detected in human transformed B‐lymphocytes." @default.
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• W2027220003 date "1999-03-19" @default.
• W2027220003 modified "2023-10-18" @default.
• W2027220003 title "Organization and alternate splice products of the gene encoding nuclear inhibitor of protein phosphatase-1 (NIPP-1)" @default.
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• W2027220003 doi "https://doi.org/10.1046/j.1432-1327.1999.00272.x" @default.
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