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- W2027223948 abstract "The purpose of this study was to examine the effects of tricyclic antidepressants (TCA) on protein kinase C (PKC) in vivo.PKC activity in rabbit and human platelets in vivo was measured after administration of TCA and in controls.Administration of TCA increased PKC activity in rabbit and human platelets in vivo.It has been reported that activation of PKC mediates inhibition of neurotransmitter uptake and down-regulation of beta-adrenergic receptor. We suppose that TCA-induced activation of PKC may be associated, at least in part, with the mechanism of TCA.Other signal transduction systems, such as those of protein kinase A, protein kinase G, and cyclic-AMP, also affect neurotransmitter uptake and/or down-regulation. In this study, the relationship between the TCA-PKC system and other signal transduction systems was not investigated." @default.
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- W2027223948 date "2002-08-01" @default.
- W2027223948 modified "2023-09-25" @default.
- W2027223948 title "Effects of tricyclic antidepressants on protein kinase C activity in rabbit and human platelets in vivo" @default.
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- W2027223948 doi "https://doi.org/10.1016/s0165-0327(01)00333-0" @default.
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