Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027235352> ?p ?o ?g. }
- W2027235352 endingPage "20" @default.
- W2027235352 startingPage "14" @default.
- W2027235352 abstract "Killer lectin-like receptor CD94 on natural killer cells can bind to HLA-E, α2,3-NeuAc-containing glycoproteins, and heparin. Using the glutathione-S-transferase-fused CD94 (rGST-CD94), we investigated its binding to plates coated with α2,3-NeuAc-containing transferrin secreted by HepG2 cells (HepTF) and sulfate-containing glycanconjugated BSA. rGST-CD94 bound directly to several glycans with similar high affinities: rGST-CD94 bound to heparin- BSA, heparan sulfate-BSA, fucoidan-BSA, λ-carrageenan-BSA, and HepTF with Kd values of 36 nM, 141 nM, 36 nM, 92 nM and 84 nM, respectively. Different mutants of rGST-CD94 were generated by site-directed mutagenesis. Mutants N160A and C166G had reduced binding to sulfated glycans and HepTF, also F114A, L162A, D163A, and E164A showed reduced binding to sulfated glycans with some variability. These results indicated that CD94 interacts with sulfated glycans and α2,3-NeuAc-containing glycoproteins suggesting that glycan binding sites in CD94 partially overlap with the HLA-E binding sites to modulate natural killer cell-dependent cytotoxicity." @default.
- W2027235352 created "2016-06-24" @default.
- W2027235352 creator A5011304225 @default.
- W2027235352 creator A5011933518 @default.
- W2027235352 creator A5017814007 @default.
- W2027235352 creator A5018224851 @default.
- W2027235352 creator A5047124158 @default.
- W2027235352 creator A5070533584 @default.
- W2027235352 creator A5077724730 @default.
- W2027235352 date "2011-06-23" @default.
- W2027235352 modified "2023-10-17" @default.
- W2027235352 title "Binding Properties of CD94 to Sulfated Glycans and α2,3-NeuAc- Containing Glycoproteins and Mutagenesis Analysis" @default.
- W2027235352 cites W1533245092 @default.
- W2027235352 cites W1605872885 @default.
- W2027235352 cites W1969448071 @default.
- W2027235352 cites W1977339743 @default.
- W2027235352 cites W1978241413 @default.
- W2027235352 cites W1978815390 @default.
- W2027235352 cites W1980376659 @default.
- W2027235352 cites W1981706626 @default.
- W2027235352 cites W1983996935 @default.
- W2027235352 cites W1995148245 @default.
- W2027235352 cites W1996269830 @default.
- W2027235352 cites W2001475156 @default.
- W2027235352 cites W2007851855 @default.
- W2027235352 cites W2010126397 @default.
- W2027235352 cites W2010980655 @default.
- W2027235352 cites W2014208459 @default.
- W2027235352 cites W2021036829 @default.
- W2027235352 cites W2021130116 @default.
- W2027235352 cites W2022609860 @default.
- W2027235352 cites W2053244697 @default.
- W2027235352 cites W2054150065 @default.
- W2027235352 cites W2069539522 @default.
- W2027235352 cites W2069565722 @default.
- W2027235352 cites W2074736160 @default.
- W2027235352 cites W2075207038 @default.
- W2027235352 cites W2083920899 @default.
- W2027235352 cites W2084863090 @default.
- W2027235352 cites W2095529707 @default.
- W2027235352 cites W2096815761 @default.
- W2027235352 cites W2099053491 @default.
- W2027235352 cites W2102240846 @default.
- W2027235352 cites W2112998064 @default.
- W2027235352 cites W2116171543 @default.
- W2027235352 cites W2119531959 @default.
- W2027235352 cites W2119809419 @default.
- W2027235352 cites W2122745552 @default.
- W2027235352 cites W2137006225 @default.
- W2027235352 cites W2144891041 @default.
- W2027235352 cites W2171709048 @default.
- W2027235352 doi "https://doi.org/10.2174/1874070701105010014" @default.
- W2027235352 hasPublicationYear "2011" @default.
- W2027235352 type Work @default.
- W2027235352 sameAs 2027235352 @default.
- W2027235352 citedByCount "1" @default.
- W2027235352 countsByYear W20272353522012 @default.
- W2027235352 crossrefType "journal-article" @default.
- W2027235352 hasAuthorship W2027235352A5011304225 @default.
- W2027235352 hasAuthorship W2027235352A5011933518 @default.
- W2027235352 hasAuthorship W2027235352A5017814007 @default.
- W2027235352 hasAuthorship W2027235352A5018224851 @default.
- W2027235352 hasAuthorship W2027235352A5047124158 @default.
- W2027235352 hasAuthorship W2027235352A5070533584 @default.
- W2027235352 hasAuthorship W2027235352A5077724730 @default.
- W2027235352 hasBestOaLocation W20272353521 @default.
- W2027235352 hasConcept C104317684 @default.
- W2027235352 hasConcept C108625454 @default.
- W2027235352 hasConcept C143065580 @default.
- W2027235352 hasConcept C155138218 @default.
- W2027235352 hasConcept C16318435 @default.
- W2027235352 hasConcept C185592680 @default.
- W2027235352 hasConcept C206212055 @default.
- W2027235352 hasConcept C2777557582 @default.
- W2027235352 hasConcept C2778041096 @default.
- W2027235352 hasConcept C55493867 @default.
- W2027235352 hasConceptScore W2027235352C104317684 @default.
- W2027235352 hasConceptScore W2027235352C108625454 @default.
- W2027235352 hasConceptScore W2027235352C143065580 @default.
- W2027235352 hasConceptScore W2027235352C155138218 @default.
- W2027235352 hasConceptScore W2027235352C16318435 @default.
- W2027235352 hasConceptScore W2027235352C185592680 @default.
- W2027235352 hasConceptScore W2027235352C206212055 @default.
- W2027235352 hasConceptScore W2027235352C2777557582 @default.
- W2027235352 hasConceptScore W2027235352C2778041096 @default.
- W2027235352 hasConceptScore W2027235352C55493867 @default.
- W2027235352 hasIssue "1" @default.
- W2027235352 hasLocation W20272353521 @default.
- W2027235352 hasOpenAccess W2027235352 @default.
- W2027235352 hasPrimaryLocation W20272353521 @default.
- W2027235352 hasRelatedWork W1496730816 @default.
- W2027235352 hasRelatedWork W1992081767 @default.
- W2027235352 hasRelatedWork W2047516844 @default.
- W2027235352 hasRelatedWork W2090553026 @default.
- W2027235352 hasRelatedWork W2159145059 @default.
- W2027235352 hasRelatedWork W2169363379 @default.
- W2027235352 hasRelatedWork W2414975270 @default.
- W2027235352 hasRelatedWork W2497831928 @default.