Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027238403> ?p ?o ?g. }
- W2027238403 endingPage "1309" @default.
- W2027238403 startingPage "1299" @default.
- W2027238403 abstract "Since the cyclo-oxygenase (COX) isoform-nonselective inhibitor indomethacin is known to modify intestinal motility, we analysed the effects of COX-1 and COX-2 inhibition on intestinal peristalsis. Peristalsis in isolated segments of the guinea-pig small intestine was triggered by a rise of the intraluminal pressure and recorded via the pressure changes associated with peristalsis. The COX-1 inhibitor SC-560, the COX-2 inhibitor NS-398 (both at 0.1 – 1 μM) and the isoform-nonselective inhibitors flurbiprofen (0.01 – 10 μM) and piroxicam (0.1 – 50 μM) were without major influence on peristalsis, whereas indomethacin and etodolac (0.1 – 10 μM) disturbed the regularity of peristalsis by causing nonpropulsive circular muscle contractions. Radioimmunoassay measurements showed that SC-560, NS-398, indomethacin and etodolac (each at 1 μM) suppressed the release of 6-keto-prostaglandin F1α (6-keto-PGF1α) from the intestinal segments. Reverse transcription – polymerase chain reaction tests revealed that, relative to glyceraldehyde-3 phosphate dehydrogenase ribonucleic acid, the expression of COX-1 mRNA increased by a factor of 2.0 whereas that of COX-2 mRNA rose by a factor of 7.9 during the 2 h experimental period. Pharmacological experiments indicated that the action of indomethacin to disturb intestinal peristalsis was unrelated to inhibition of L-type calcium channels, adenosine triphosphate-sensitive potassium channels or phosphodiesterase type IV. These results show that selective inhibition of COX-1 and COX-2 does not grossly alter peristaltic motor activity in the guinea-pig isolated small intestine and that the effect of indomethacin to disturb the regular pattern of propulsive motility in this species is unrelated to COX inhibition. British Journal of Pharmacology (2001) 132, 1299–1309; doi:10.1038/sj.bjp.0703940" @default.
- W2027238403 created "2016-06-24" @default.
- W2027238403 creator A5005473061 @default.
- W2027238403 creator A5006321692 @default.
- W2027238403 creator A5010376990 @default.
- W2027238403 creator A5024491800 @default.
- W2027238403 creator A5080725449 @default.
- W2027238403 date "2001-03-01" @default.
- W2027238403 modified "2023-09-27" @default.
- W2027238403 title "Disturbance of peristalsis in the guinea-pig isolated small intestine by indomethacin, but not cyclo-oxygenase isoform-selective inhibitors" @default.
- W2027238403 cites W1687095011 @default.
- W2027238403 cites W1923597418 @default.
- W2027238403 cites W1968645000 @default.
- W2027238403 cites W1969042898 @default.
- W2027238403 cites W1973617905 @default.
- W2027238403 cites W1974450761 @default.
- W2027238403 cites W1975655744 @default.
- W2027238403 cites W1981294565 @default.
- W2027238403 cites W1986665454 @default.
- W2027238403 cites W1992432153 @default.
- W2027238403 cites W2002273622 @default.
- W2027238403 cites W2004293605 @default.
- W2027238403 cites W2013956200 @default.
- W2027238403 cites W2017921919 @default.
- W2027238403 cites W2018583526 @default.
- W2027238403 cites W2023887529 @default.
- W2027238403 cites W2024275518 @default.
- W2027238403 cites W2030979666 @default.
- W2027238403 cites W2034679499 @default.
- W2027238403 cites W2036239330 @default.
- W2027238403 cites W2038410983 @default.
- W2027238403 cites W2039440412 @default.
- W2027238403 cites W2042383034 @default.
- W2027238403 cites W2045493775 @default.
- W2027238403 cites W2050767344 @default.
- W2027238403 cites W2053581580 @default.
- W2027238403 cites W2054282581 @default.
- W2027238403 cites W2064270753 @default.
- W2027238403 cites W2064982621 @default.
- W2027238403 cites W2065154686 @default.
- W2027238403 cites W2065777603 @default.
- W2027238403 cites W2072367560 @default.
- W2027238403 cites W2072475704 @default.
- W2027238403 cites W2074917122 @default.
- W2027238403 cites W2076456285 @default.
- W2027238403 cites W2082510463 @default.
- W2027238403 cites W2088804413 @default.
- W2027238403 cites W2093096083 @default.
- W2027238403 cites W2102368544 @default.
- W2027238403 cites W2123979253 @default.
- W2027238403 cites W2125471714 @default.
- W2027238403 cites W2272087247 @default.
- W2027238403 cites W244387317 @default.
- W2027238403 cites W2473874580 @default.
- W2027238403 cites W84643873 @default.
- W2027238403 doi "https://doi.org/10.1038/sj.bjp.0703940" @default.
- W2027238403 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572673" @default.
- W2027238403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11250881" @default.
- W2027238403 hasPublicationYear "2001" @default.
- W2027238403 type Work @default.
- W2027238403 sameAs 2027238403 @default.
- W2027238403 citedByCount "19" @default.
- W2027238403 countsByYear W20272384032014 @default.
- W2027238403 countsByYear W20272384032016 @default.
- W2027238403 countsByYear W20272384032021 @default.
- W2027238403 countsByYear W20272384032023 @default.
- W2027238403 crossrefType "journal-article" @default.
- W2027238403 hasAuthorship W2027238403A5005473061 @default.
- W2027238403 hasAuthorship W2027238403A5006321692 @default.
- W2027238403 hasAuthorship W2027238403A5010376990 @default.
- W2027238403 hasAuthorship W2027238403A5024491800 @default.
- W2027238403 hasAuthorship W2027238403A5080725449 @default.
- W2027238403 hasBestOaLocation W20272384031 @default.
- W2027238403 hasConcept C126322002 @default.
- W2027238403 hasConcept C134018914 @default.
- W2027238403 hasConcept C181199279 @default.
- W2027238403 hasConcept C185592680 @default.
- W2027238403 hasConcept C206813253 @default.
- W2027238403 hasConcept C2777807940 @default.
- W2027238403 hasConcept C2777882243 @default.
- W2027238403 hasConcept C2779689624 @default.
- W2027238403 hasConcept C2781000538 @default.
- W2027238403 hasConcept C54355233 @default.
- W2027238403 hasConcept C55493867 @default.
- W2027238403 hasConcept C58207958 @default.
- W2027238403 hasConcept C71924100 @default.
- W2027238403 hasConcept C86803240 @default.
- W2027238403 hasConcept C98274493 @default.
- W2027238403 hasConceptScore W2027238403C126322002 @default.
- W2027238403 hasConceptScore W2027238403C134018914 @default.
- W2027238403 hasConceptScore W2027238403C181199279 @default.
- W2027238403 hasConceptScore W2027238403C185592680 @default.
- W2027238403 hasConceptScore W2027238403C206813253 @default.
- W2027238403 hasConceptScore W2027238403C2777807940 @default.
- W2027238403 hasConceptScore W2027238403C2777882243 @default.
- W2027238403 hasConceptScore W2027238403C2779689624 @default.
- W2027238403 hasConceptScore W2027238403C2781000538 @default.
- W2027238403 hasConceptScore W2027238403C54355233 @default.