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- W2027238557 abstract "Membrane-induced interactions can play a significant role in the spatial distribution of membrane-bound proteins. We develop a model that combines a continuum description of lipid bilayers with a discrete particle model of proteins to probe the emerging structure of the combined membrane-protein system. Our model takes into account the membrane's elastic behavior, the steric repulsion between proteins, and the quenching of membrane shape fluctuations due to the presence of the proteins. We employ coupled Langevin equations to describe the dynamics of the system. We show that coupling to the membrane induces an attractive interaction among proteins, which may contribute to the clustering of proteins in biological membranes. We further demonstrate that lateral protein diffusion is enhanced by fluctuating forces generated by membrane undulations." @default.
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- W2027238557 date "2015-01-01" @default.
- W2027238557 modified "2023-09-30" @default.
- W2027238557 title "The Effect of Lipid Bilayers on Membrane-Bound Proteins" @default.
- W2027238557 doi "https://doi.org/10.1016/j.bpj.2014.11.457" @default.
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