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• W2027243097 abstract "The role played by glycoprotein (GP) IIb/IIIa inhibitors has continuously evolved from the initial introduction in mid 90 s until the most recent guidelines for treating acute coronary syndromes, and competed with a wider use of ADP inhibitors and novel anticoagulant drugs, to the extent that they stepped down from class I to class II recommendation in the routine setting of acute coronary syndromes. As a consequence, GP IIb/IIIa use was greatly narrowed. The purpose of this review is to define the roles that GP IIb/IIIa inhibitors may still have in acute ischemic settings by explaining why in high risk patients they might be preferable and / or whether they might be added to ADP inhibitors also emphasizing the underlying mechanistic actions. It is concluded that there might be a more extensive use of GP IIb/IIIa inhibitors in patients presenting with acute coronary syndromes, strictly based on the definition for a high risk procedure: complexity, angiographic characteristics and patient ' s risk profile, regardless whether STEMI or NSTEMI. The positive elements one should appreciate in GP IIb/IIIa inhibitors are: efficacy, rapid onset and reversibility of action, absence of pharmacogenomic variability, pharmacoeconomic considerations and the possibility of intracoronary administration. Cardiol Res. 2013;4(1):1-7 doi: https://doi.org/10.4021/cr251w" @default.
• W2027243097 created "2016-06-24" @default.
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• W2027243097 date "2013-01-01" @default.
• W2027243097 modified "2023-10-05" @default.
• W2027243097 title "Is There Still a Role for Glycoprotein IIb/IIIa Antagonists in Acute Coronary Syndromes?" @default.
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• W2027243097 doi "https://doi.org/10.4021/cr251w" @default.
• W2027243097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5358181" @default.
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• W2027243097 hasPublicationYear "2013" @default.
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