FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027248889> ?p ?o ?g. }

• W2027248889 endingPage "333" @default.
• W2027248889 startingPage "326" @default.
• W2027248889 abstract "The receptor for the homeostatic T cell cytokine interleukin-7 (IL-7Ralpha) has recently shown genetic association to multiple sclerosis (MS). To investigate the functional contribution of IL-7Ralpha polymorphisms to the pathogenesis of MS, we correlated the IL-7Ralpha haplotypes with different T cell parameters in a group of MS patients and healthy controls. We show that carriers of one of the four IL-7Ralpha haplotypes (Hap4) show a higher expression of IL-7Ralpha (CD127) on their CD4(+) T cells, compared with noncarriers (P=0.04). Moreover, Hap4 carriers possess higher frequencies of recent thymic emigrants (RTEs, CD31(+)) in both the regulatory T cell (Treg; P=0.007) and conventional T cell (Tconv) population (P=0.0001). This effect is most pronounced within the MS population (Treg, P=0.0077; Tconv, P=0.0007), whereas in healthy controls significance was only reached for Tconv (P=0.043; Treg, P=0.11). Because previous studies showed a decreased RTE-Treg frequency in MS patients compared to healthy subjects, we here conclude that this decrease is localized within the MS population of non-Hap4 carriers. In conclusion, our findings suggest that IL-7Ralpha polymorphisms can influence T cell development and homeostasis, and thereby contribute to the altered immune regulation associated with disease development in patients with MS." @default.
• W2027248889 created "2016-06-24" @default.
• W2027248889 creator A5000551742 @default.
• W2027248889 creator A5002682151 @default.
• W2027248889 creator A5042210002 @default.
• W2027248889 creator A5051450048 @default.
• W2027248889 creator A5076078904 @default.
• W2027248889 creator A5088390671 @default.
• W2027248889 creator A5091395853 @default.
• W2027248889 date "2010-01-14" @default.
• W2027248889 modified "2023-10-11" @default.
• W2027248889 title "Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants" @default.
• W2027248889 cites W1782419634 @default.
• W2027248889 cites W1994009925 @default.
• W2027248889 cites W1999427630 @default.
• W2027248889 cites W2003587486 @default.
• W2027248889 cites W2037638393 @default.
• W2027248889 cites W2047370802 @default.
• W2027248889 cites W2051917792 @default.
• W2027248889 cites W2058502868 @default.
• W2027248889 cites W2059239713 @default.
• W2027248889 cites W2067211970 @default.
• W2027248889 cites W2070299455 @default.
• W2027248889 cites W2070587287 @default.
• W2027248889 cites W2083358433 @default.
• W2027248889 cites W2091886117 @default.
• W2027248889 cites W2096632716 @default.
• W2027248889 cites W2124941727 @default.
• W2027248889 cites W2135790224 @default.
• W2027248889 cites W2141231618 @default.
• W2027248889 cites W2156860214 @default.
• W2027248889 cites W2156964052 @default.
• W2027248889 cites W2164392039 @default.
• W2027248889 cites W2166086426 @default.
• W2027248889 cites W2168628806 @default.
• W2027248889 cites W2171556560 @default.
• W2027248889 cites W2171953655 @default.
• W2027248889 cites W4211261427 @default.
• W2027248889 doi "https://doi.org/10.1038/gene.2009.106" @default.
• W2027248889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20072142" @default.
• W2027248889 hasPublicationYear "2010" @default.
• W2027248889 type Work @default.
• W2027248889 sameAs 2027248889 @default.
• W2027248889 citedByCount "50" @default.
• W2027248889 countsByYear W20272488892012 @default.
• W2027248889 countsByYear W20272488892013 @default.
• W2027248889 countsByYear W20272488892014 @default.
• W2027248889 countsByYear W20272488892015 @default.
• W2027248889 countsByYear W20272488892016 @default.
• W2027248889 countsByYear W20272488892017 @default.
• W2027248889 countsByYear W20272488892018 @default.
• W2027248889 countsByYear W20272488892020 @default.
• W2027248889 countsByYear W20272488892021 @default.
• W2027248889 countsByYear W20272488892022 @default.
• W2027248889 crossrefType "journal-article" @default.
• W2027248889 hasAuthorship W2027248889A5000551742 @default.
• W2027248889 hasAuthorship W2027248889A5002682151 @default.
• W2027248889 hasAuthorship W2027248889A5042210002 @default.
• W2027248889 hasAuthorship W2027248889A5051450048 @default.
• W2027248889 hasAuthorship W2027248889A5076078904 @default.
• W2027248889 hasAuthorship W2027248889A5088390671 @default.
• W2027248889 hasAuthorship W2027248889A5091395853 @default.
• W2027248889 hasBestOaLocation W20272488891 @default.
• W2027248889 hasConcept C104317684 @default.
• W2027248889 hasConcept C123982805 @default.
• W2027248889 hasConcept C170493617 @default.
• W2027248889 hasConcept C180754005 @default.
• W2027248889 hasConcept C197754878 @default.
• W2027248889 hasConcept C203014093 @default.
• W2027248889 hasConcept C2776090121 @default.
• W2027248889 hasConcept C2778690821 @default.
• W2027248889 hasConcept C2780942790 @default.
• W2027248889 hasConcept C2908647359 @default.
• W2027248889 hasConcept C54355233 @default.
• W2027248889 hasConcept C71924100 @default.
• W2027248889 hasConcept C74172505 @default.
• W2027248889 hasConcept C79484868 @default.
• W2027248889 hasConcept C86803240 @default.
• W2027248889 hasConcept C8891405 @default.
• W2027248889 hasConcept C99454951 @default.
• W2027248889 hasConceptScore W2027248889C104317684 @default.
• W2027248889 hasConceptScore W2027248889C123982805 @default.
• W2027248889 hasConceptScore W2027248889C170493617 @default.
• W2027248889 hasConceptScore W2027248889C180754005 @default.
• W2027248889 hasConceptScore W2027248889C197754878 @default.
• W2027248889 hasConceptScore W2027248889C203014093 @default.
• W2027248889 hasConceptScore W2027248889C2776090121 @default.
• W2027248889 hasConceptScore W2027248889C2778690821 @default.
• W2027248889 hasConceptScore W2027248889C2780942790 @default.
• W2027248889 hasConceptScore W2027248889C2908647359 @default.
• W2027248889 hasConceptScore W2027248889C54355233 @default.
• W2027248889 hasConceptScore W2027248889C71924100 @default.
• W2027248889 hasConceptScore W2027248889C74172505 @default.
• W2027248889 hasConceptScore W2027248889C79484868 @default.
• W2027248889 hasConceptScore W2027248889C86803240 @default.
• W2027248889 hasConceptScore W2027248889C8891405 @default.
• W2027248889 hasConceptScore W2027248889C99454951 @default.
• W2027248889 hasIssue "4" @default.

• next