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• W2027285987 endingPage "20" @default.
• W2027285987 startingPage "1" @default.
• W2027285987 abstract "Choline acetyltransferase and vesicular acetylcholine-transporter genes are adjacent and coregulated. They define a cholinergic locus that can be turned on under the control of several factors, including the neurotrophins and the cytokines. Hirschprung's disease, or congenital megacolon, is characterized by agenesis of intramural cholinergic ganglia in the colorectal region. It results from mutations of the RET (GDNF-activated) and the endothelin-receptor genes, causing a disregulation in the cholinergic locus. Using cultured cells, it was shown that the cholinergic locus and the proteins involved in acetylcholine (ACh) release can be expressed separately ACh release could be demonstrated by means of biochemical and electrophysiological assays even in noncholinergic cells following preloading with the transmitter. Some noncholinergic or even nonneuronal cell types were found to be capable of releasing ACh quanta. In contrast, other cells were incompetent for ACh release. Among them, neuroblastoma N18TG-2 cells were rendered release-competent by transfection with the mediatophore gene. Mediatophore is an ACh-translocating protein that has been purified from plasma membranes of Torpedo nerve terminal; it confers a specificity for ACh to the release process. The mediatophores are activated by Ca2+; but with a slower time course, they can be desensitized by Ca2+. A strictly regulated calcium microdomain controls the synchronized release of ACh quanta at the active zone. In addition to ACh and ATP, synaptic vesicles have an ATP-dependent Ca2+ uptake system; they transiently accumulate Ca2+ after a brief period of stimulation. Those vesicles that are docked close to Ca2+ channels are therefore in the best position to control the profile and dynamics of the Ca2+ microdomains. Thus, vesicles and their whole set of associated proteins (SNAREs and others) are essential for the regulation of the release mechanism in which the mediatophore seems to play a key role." @default.
• W2027285987 created "2016-06-24" @default.
• W2027285987 creator A5075707459 @default.
• W2027285987 creator A5083593653 @default.
• W2027285987 date "1998-02-01" @default.
• W2027285987 modified "2023-10-05" @default.
• W2027285987 title "Acetylcholine release and the cholinergic genomic locus" @default.
• W2027285987 cites W1136740326 @default.
• W2027285987 cites W1482148559 @default.
• W2027285987 cites W1493049774 @default.
• W2027285987 cites W1544919124 @default.
• W2027285987 cites W1587500322 @default.
• W2027285987 cites W1595148250 @default.
• W2027285987 cites W1601928222 @default.
• W2027285987 cites W1612081295 @default.
• W2027285987 cites W1717056034 @default.
• W2027285987 cites W1892382736 @default.
• W2027285987 cites W1935132610 @default.
• W2027285987 cites W1950325542 @default.
• W2027285987 cites W1968312456 @default.
• W2027285987 cites W1968654018 @default.
• W2027285987 cites W1968684596 @default.
• W2027285987 cites W1971016259 @default.
• W2027285987 cites W1971434876 @default.
• W2027285987 cites W1971908262 @default.
• W2027285987 cites W1975429624 @default.
• W2027285987 cites W1976472821 @default.
• W2027285987 cites W1979557791 @default.
• W2027285987 cites W1983169741 @default.
• W2027285987 cites W1983982481 @default.
• W2027285987 cites W1984308359 @default.
• W2027285987 cites W1985222283 @default.
• W2027285987 cites W1985573675 @default.
• W2027285987 cites W1987314655 @default.
• W2027285987 cites W1987566228 @default.
• W2027285987 cites W1988591557 @default.
• W2027285987 cites W1989457545 @default.
• W2027285987 cites W1989721214 @default.
• W2027285987 cites W1990775637 @default.
• W2027285987 cites W1992740212 @default.
• W2027285987 cites W1994452959 @default.
• W2027285987 cites W1995179073 @default.
• W2027285987 cites W1999127249 @default.
• W2027285987 cites W2000937423 @default.
• W2027285987 cites W2002644147 @default.
• W2027285987 cites W2004420701 @default.
• W2027285987 cites W2004828839 @default.
• W2027285987 cites W2005601991 @default.
• W2027285987 cites W2006166230 @default.
• W2027285987 cites W2007266423 @default.
• W2027285987 cites W2007982098 @default.
• W2027285987 cites W2008334722 @default.
• W2027285987 cites W2009855270 @default.
• W2027285987 cites W2014078232 @default.
• W2027285987 cites W2016266703 @default.
• W2027285987 cites W2016278286 @default.
• W2027285987 cites W2019027388 @default.
• W2027285987 cites W2020326837 @default.
• W2027285987 cites W2020405906 @default.
• W2027285987 cites W2020832020 @default.
• W2027285987 cites W2024058819 @default.
• W2027285987 cites W2025149315 @default.
• W2027285987 cites W2027315162 @default.
• W2027285987 cites W2027322371 @default.
• W2027285987 cites W2027653931 @default.
• W2027285987 cites W2028980876 @default.
• W2027285987 cites W2029128430 @default.
• W2027285987 cites W2029663217 @default.
• W2027285987 cites W2030896099 @default.
• W2027285987 cites W2031410608 @default.
• W2027285987 cites W2032171663 @default.
• W2027285987 cites W2032562864 @default.
• W2027285987 cites W2032985825 @default.
• W2027285987 cites W2033410467 @default.
• W2027285987 cites W2033500343 @default.
• W2027285987 cites W2033995553 @default.
• W2027285987 cites W2035781629 @default.
• W2027285987 cites W2036834043 @default.
• W2027285987 cites W2036915928 @default.
• W2027285987 cites W2037889356 @default.
• W2027285987 cites W2038004255 @default.
• W2027285987 cites W2038218988 @default.
• W2027285987 cites W2038316599 @default.
• W2027285987 cites W2038855142 @default.
• W2027285987 cites W2039683547 @default.
• W2027285987 cites W2039898903 @default.
• W2027285987 cites W2043001069 @default.
• W2027285987 cites W2044162798 @default.
• W2027285987 cites W2044761914 @default.
• W2027285987 cites W2045050345 @default.
• W2027285987 cites W2048266248 @default.
• W2027285987 cites W2050963778 @default.
• W2027285987 cites W2051998916 @default.
• W2027285987 cites W2052744293 @default.
• W2027285987 cites W2054810445 @default.
• W2027285987 cites W2060526310 @default.
• W2027285987 cites W2062238606 @default.
• W2027285987 cites W2062403816 @default.

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