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• W2027289338 abstract "The effects of 12 steroids on RNA polymerase activity of aggregate enzyme preparations of isolated thymus nuclei were studied. Cortisol, cortisone, prednisolone, testosterone and dihydrotestosterone decreased RNA synthesis; the other structurally related steroids showed no effect. The inhibition of RNA synthesis was observed only if the assay for RNA polymerase activity was conducted with the sediment of lysed nuclei or with the aggregate enzyme preparations, but not with whole nuclei. The effects of the hormones in the presence of α-amanitin suggest, that cortisol inhibits preferentially ribosomal RNA synthesis, whereas testosterone affects DNA like RNA." @default.
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• W2027289338 date "1971-11-01" @default.
• W2027289338 modified "2023-09-27" @default.
• W2027289338 title "Inhibitory action of steroid hormones on RNA synthesis of isolated thymus nuclei" @default.
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• W2027289338 doi "https://doi.org/10.1016/0005-2787(71)90692-7" @default.
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