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- W2027291294 abstract "Abstract A recent report from this laboratory demonstrated that the BALB/c myeloma retroviruses, MO-21 and FL-1, have a polytropic host range and exhibit “mink cell focus-inducing” (MCF) activity. Because previous MCF isolates have been shown to possess a recombinant envelope (env) gene, we undertook neutralization and peptide mapping studies to analyze the envelope proteins of MO-21 and FL-1 viruses and compare them to various prototype murine retroviruses. Like other MCF viruses, the infectivity of the myeloma viruses was inhibited by normal mouse serum. Two-dimensional peptide mapping data show that the viral envelope protein (gp70) of MO-21 and FL-1 has several distinct peptides which distinguish them from the gp70 of any of the prototype viruses we analyzed. Unlike other MCF viruses, the gp70s of MO-21 and FL-1 are indistinguishable from one another. These results suggest that these MCF retroviruses may not be (env) gene recombinants. MO-21 FL-1 viruses also contain another viral-coded envelope protein which has an apparent higher molecular weight than the gp70. The possible significance of this gp70-like protein is discussed." @default.
- W2027291294 created "2016-06-24" @default.
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- W2027291294 date "1981-01-01" @default.
- W2027291294 modified "2023-09-27" @default.
- W2027291294 title "Envelope proteins of the BALB/c myeloma mink cell focus-inducing (MCF) viruses" @default.
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- W2027291294 doi "https://doi.org/10.1016/0042-6822(81)90454-2" @default.
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