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- W2027296122 abstract "Although it is widely known that immunological, hormonal and nociceptive mechanisms are altered by exposure to repeated stress, the interplaying roles of each function in the development of post-stress hyperalgesia are not completely clear. Thus, we wanted to establish how interleukin 1-beta (IL-1β), corticosterone and microglia interact to contribute in the development of hyperalgesia following repeated forced swim. Rats were subjected to either forced swim, sham swim or non-conditioned. Each group was then treated with minocycline, ketoconazole, or saline. Thermal nociception was measured via the hot plate test, before and after the behavioral conditioning, whereas blood and lumbar spinal cord tissue samples were obtained at the end of the protocol. Serum levels of corticosterone, spinal tissue concentration of IL-1β and spinal OX-42 labeling (microglial marker) were determined. Rats exposed to forced swim stress developed thermal hyperalgesia along with elevated spinal tissue IL-1β, increased OX-42 labeling and relatively diminished serum corticosterone. Pre-treatment with minocycline and ketoconazole prevented the development of thermal hyperalgesia and the increase in IL-1β, without significantly modifying serum corticosterone. These results suggest that the development of forced swim-induced thermal hyperalgesia requires the simultaneous presence of increased spinal IL-1β, microglial activation, and relatively decreased serum corticosterone." @default.
- W2027296122 created "2016-06-24" @default.
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- W2027296122 date "2014-01-01" @default.
- W2027296122 modified "2023-10-16" @default.
- W2027296122 title "Central immune overactivation in the presence of reduced plasma corticosterone contributes to swim stress-induced hyperalgesia" @default.
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- W2027296122 doi "https://doi.org/10.1016/j.brainresbull.2013.11.003" @default.
- W2027296122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24316519" @default.
- W2027296122 hasPublicationYear "2014" @default.
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