Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027296541> ?p ?o ?g. }
- W2027296541 endingPage "1282" @default.
- W2027296541 startingPage "1276" @default.
- W2027296541 abstract "Many zinc cluster proteins have been shown to play a role in the transcriptional regulation of glucose-repressible genes during glucose exhaustion and diauxic shift. Here, we studied an additional member of this family called Yer184c (herein called Tog1) for transcriptional regulator of oleate. Our results showed that a Δtog1 strain displays impaired growth with several non-fermentable carbons. Tog1 is also implicated in oxidative stress tolerance. Importantly, during the glucose–oleate shift, combined results from quantitative real time-PCR and chromatin immunoprecipitation (ChIP) experiments showed that Tog1 acts as a direct activator of oleate utilizing genes, encoded key enzymes in β-Oxidation and NADPH regeneration (POX1, FOX2, POT1 and IDP2), the glyoxylate shunt (MLS1 and ICL1), and gluconeogenesis (PCK1 and FBP1). A transmission electron microscopy (TEM) analysis of the Δtog1 strain assayed with oleate also revealed a substantial decrease in peroxisome abundance that is vital for fatty acid oxidation. Overall, our results clearly demonstrated that Tog1 is a newly characterized zinc cluster regulator that functions in the complex network of non-fermentable carbon metabolism in Saccharomyces cerevisiae." @default.
- W2027296541 created "2016-06-24" @default.
- W2027296541 creator A5004006540 @default.
- W2027296541 creator A5025084076 @default.
- W2027296541 creator A5044468055 @default.
- W2027296541 date "2014-08-01" @default.
- W2027296541 modified "2023-09-24" @default.
- W2027296541 title "The novel zinc cluster regulator Tog1 plays important roles in oleate utilization and oxidative stress response in Saccharomyces cerevisiae" @default.
- W2027296541 cites W1539988911 @default.
- W2027296541 cites W1599051410 @default.
- W2027296541 cites W1755414476 @default.
- W2027296541 cites W1962823952 @default.
- W2027296541 cites W1975638954 @default.
- W2027296541 cites W1984354326 @default.
- W2027296541 cites W1992005386 @default.
- W2027296541 cites W1995754833 @default.
- W2027296541 cites W2011435420 @default.
- W2027296541 cites W2014477641 @default.
- W2027296541 cites W2024014185 @default.
- W2027296541 cites W2027581706 @default.
- W2027296541 cites W2031270050 @default.
- W2027296541 cites W2046375608 @default.
- W2027296541 cites W2059382856 @default.
- W2027296541 cites W2072693949 @default.
- W2027296541 cites W2080408951 @default.
- W2027296541 cites W2107277218 @default.
- W2027296541 cites W2108668801 @default.
- W2027296541 cites W2112546055 @default.
- W2027296541 cites W2113976732 @default.
- W2027296541 cites W2116418521 @default.
- W2027296541 cites W2117403951 @default.
- W2027296541 cites W2122170733 @default.
- W2027296541 cites W2122576785 @default.
- W2027296541 cites W2124479692 @default.
- W2027296541 cites W2132454572 @default.
- W2027296541 cites W2142494212 @default.
- W2027296541 cites W2149503684 @default.
- W2027296541 cites W2162725033 @default.
- W2027296541 cites W2165011536 @default.
- W2027296541 cites W2169875902 @default.
- W2027296541 cites W2170322333 @default.
- W2027296541 cites W2400977278 @default.
- W2027296541 cites W4242654813 @default.
- W2027296541 doi "https://doi.org/10.1016/j.bbrc.2014.06.128" @default.
- W2027296541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24998441" @default.
- W2027296541 hasPublicationYear "2014" @default.
- W2027296541 type Work @default.
- W2027296541 sameAs 2027296541 @default.
- W2027296541 citedByCount "10" @default.
- W2027296541 countsByYear W20272965412015 @default.
- W2027296541 countsByYear W20272965412016 @default.
- W2027296541 countsByYear W20272965412017 @default.
- W2027296541 countsByYear W20272965412018 @default.
- W2027296541 countsByYear W20272965412020 @default.
- W2027296541 countsByYear W20272965412022 @default.
- W2027296541 countsByYear W20272965412023 @default.
- W2027296541 crossrefType "journal-article" @default.
- W2027296541 hasAuthorship W2027296541A5004006540 @default.
- W2027296541 hasAuthorship W2027296541A5025084076 @default.
- W2027296541 hasAuthorship W2027296541A5044468055 @default.
- W2027296541 hasConcept C101762097 @default.
- W2027296541 hasConcept C104317684 @default.
- W2027296541 hasConcept C127078168 @default.
- W2027296541 hasConcept C134320426 @default.
- W2027296541 hasConcept C150194340 @default.
- W2027296541 hasConcept C165267168 @default.
- W2027296541 hasConcept C185592680 @default.
- W2027296541 hasConcept C27153228 @default.
- W2027296541 hasConcept C2777576037 @default.
- W2027296541 hasConcept C55493867 @default.
- W2027296541 hasConcept C62231903 @default.
- W2027296541 hasConcept C6929976 @default.
- W2027296541 hasConcept C86803240 @default.
- W2027296541 hasConcept C88045685 @default.
- W2027296541 hasConceptScore W2027296541C101762097 @default.
- W2027296541 hasConceptScore W2027296541C104317684 @default.
- W2027296541 hasConceptScore W2027296541C127078168 @default.
- W2027296541 hasConceptScore W2027296541C134320426 @default.
- W2027296541 hasConceptScore W2027296541C150194340 @default.
- W2027296541 hasConceptScore W2027296541C165267168 @default.
- W2027296541 hasConceptScore W2027296541C185592680 @default.
- W2027296541 hasConceptScore W2027296541C27153228 @default.
- W2027296541 hasConceptScore W2027296541C2777576037 @default.
- W2027296541 hasConceptScore W2027296541C55493867 @default.
- W2027296541 hasConceptScore W2027296541C62231903 @default.
- W2027296541 hasConceptScore W2027296541C6929976 @default.
- W2027296541 hasConceptScore W2027296541C86803240 @default.
- W2027296541 hasConceptScore W2027296541C88045685 @default.
- W2027296541 hasFunder F4320322437 @default.
- W2027296541 hasFunder F4320322817 @default.
- W2027296541 hasFunder F4320322818 @default.
- W2027296541 hasFunder F4320324279 @default.
- W2027296541 hasIssue "4" @default.
- W2027296541 hasLocation W20272965411 @default.
- W2027296541 hasLocation W20272965412 @default.
- W2027296541 hasOpenAccess W2027296541 @default.
- W2027296541 hasPrimaryLocation W20272965411 @default.
- W2027296541 hasRelatedWork W1970875205 @default.