FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027312326> ?p ?o ?g. }

• W2027312326 endingPage "503" @default.
• W2027312326 startingPage "497" @default.
• W2027312326 abstract "Oxalate is a metabolic end product excreted primarily by the kidney and associated with several pathologic conditions. The most common pathologic condition involving oxalate is the formation of calcium oxalate stones in the kidney. Several stimuli have been implicated in the development of glomerular and tubular injury in various forms of immune-mediated renal diseases. The elevated level of interleukin-6 (IL-6) has been reported in the urine of kidney stone-forming patients. In the present study, we investigated the role of oxalate, a major constituent of calcium oxalate kidney stone disease, in the production of IL-6 in normal human HK-2 kidney cells.Confluent cultures of HK-2 cells (a renal epithelial cell line of human origin) were exposed to various concentrations of oxalate (0.2 to 2.0 mmol/L) and lipopolysaccharide (LPS) (0.1 and 10 mug/mL) for various time points (4-24 h) under serum-free conditions. The conditioned mediums were collected, and an IL-6 protein level was measured by enzyme-linked immunosorbent assay (ELISA). The total cellular RNA was isolated from the cells and subjected to relative quantitative reverse transcription-polymerase chain reaction (RT-PCR) to determine the expression of IL-6 mRNA. The statistical analysis of the results was carried out using the Student t test.HK-2 cells express IL-6 mRNA and protein. Oxalate increased the secretion of IL-6 protein in HK-2 cells in a concentration-dependent fashion. Oxalate exposure to HK-2 cells also induced transcriptional up-regulation of the IL-6 gene, as determined by the increased level of IL-6 mRNA expression following treatment with oxalate. Moreover, the effects of oxalate on IL-6 expression were time- and concentration-dependent. This is the first report demonstrating the regulation of IL-6 by oxalate.This study provides the first direct evidence that oxalate up-regulates the expression and secretion of IL-6 in renal epithelial cells. The increased IL-6 expression and secretion by renal epithelial cells may play a critical role in the progression of urolithiasis in hyperoxaluric conditions." @default.
• W2027312326 created "2016-06-24" @default.
• W2027312326 creator A5011661577 @default.
• W2027312326 creator A5053019599 @default.
• W2027312326 creator A5056908733 @default.
• W2027312326 creator A5067910048 @default.
• W2027312326 date "2005-08-01" @default.
• W2027312326 modified "2023-10-09" @default.
• W2027312326 title "Oxalate stimulates IL-6 production in HK-2 cells, a line of human renal proximal tubular epithelial cells" @default.
• W2027312326 cites W1777081626 @default.
• W2027312326 cites W1838497045 @default.
• W2027312326 cites W1849515690 @default.
• W2027312326 cites W1892094800 @default.
• W2027312326 cites W1904996112 @default.
• W2027312326 cites W1968709826 @default.
• W2027312326 cites W1970045335 @default.
• W2027312326 cites W1972623506 @default.
• W2027312326 cites W1997614567 @default.
• W2027312326 cites W2013215719 @default.
• W2027312326 cites W2016373119 @default.
• W2027312326 cites W2018916300 @default.
• W2027312326 cites W2029354317 @default.
• W2027312326 cites W2034464387 @default.
• W2027312326 cites W2034873907 @default.
• W2027312326 cites W2056011457 @default.
• W2027312326 cites W2059213551 @default.
• W2027312326 cites W2073769825 @default.
• W2027312326 cites W2077366591 @default.
• W2027312326 cites W2084938125 @default.
• W2027312326 cites W2094543097 @default.
• W2027312326 cites W2111034338 @default.
• W2027312326 cites W2115985004 @default.
• W2027312326 cites W2167835756 @default.
• W2027312326 cites W2433245017 @default.
• W2027312326 cites W2467029317 @default.
• W2027312326 cites W4294216491 @default.
• W2027312326 doi "https://doi.org/10.1111/j.1523-1755.2005.00427.x" @default.
• W2027312326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16014026" @default.
• W2027312326 hasPublicationYear "2005" @default.
• W2027312326 type Work @default.
• W2027312326 sameAs 2027312326 @default.
• W2027312326 citedByCount "56" @default.
• W2027312326 countsByYear W20273123262012 @default.
• W2027312326 countsByYear W20273123262014 @default.
• W2027312326 countsByYear W20273123262015 @default.
• W2027312326 countsByYear W20273123262016 @default.
• W2027312326 countsByYear W20273123262017 @default.
• W2027312326 countsByYear W20273123262018 @default.
• W2027312326 countsByYear W20273123262019 @default.
• W2027312326 countsByYear W20273123262020 @default.
• W2027312326 countsByYear W20273123262021 @default.
• W2027312326 countsByYear W20273123262022 @default.
• W2027312326 countsByYear W20273123262023 @default.
• W2027312326 crossrefType "journal-article" @default.
• W2027312326 hasAuthorship W2027312326A5011661577 @default.
• W2027312326 hasAuthorship W2027312326A5053019599 @default.
• W2027312326 hasAuthorship W2027312326A5056908733 @default.
• W2027312326 hasAuthorship W2027312326A5067910048 @default.
• W2027312326 hasBestOaLocation W20273123261 @default.
• W2027312326 hasConcept C104317684 @default.
• W2027312326 hasConcept C105580179 @default.
• W2027312326 hasConcept C126322002 @default.
• W2027312326 hasConcept C134018914 @default.
• W2027312326 hasConcept C153911025 @default.
• W2027312326 hasConcept C178790620 @default.
• W2027312326 hasConcept C185592680 @default.
• W2027312326 hasConcept C2776179656 @default.
• W2027312326 hasConcept C2776351790 @default.
• W2027312326 hasConcept C2778754761 @default.
• W2027312326 hasConcept C2779403450 @default.
• W2027312326 hasConcept C2780026642 @default.
• W2027312326 hasConcept C2780091579 @default.
• W2027312326 hasConcept C49039625 @default.
• W2027312326 hasConcept C55493867 @default.
• W2027312326 hasConcept C71924100 @default.
• W2027312326 hasConcept C86803240 @default.
• W2027312326 hasConceptScore W2027312326C104317684 @default.
• W2027312326 hasConceptScore W2027312326C105580179 @default.
• W2027312326 hasConceptScore W2027312326C126322002 @default.
• W2027312326 hasConceptScore W2027312326C134018914 @default.
• W2027312326 hasConceptScore W2027312326C153911025 @default.
• W2027312326 hasConceptScore W2027312326C178790620 @default.
• W2027312326 hasConceptScore W2027312326C185592680 @default.
• W2027312326 hasConceptScore W2027312326C2776179656 @default.
• W2027312326 hasConceptScore W2027312326C2776351790 @default.
• W2027312326 hasConceptScore W2027312326C2778754761 @default.
• W2027312326 hasConceptScore W2027312326C2779403450 @default.
• W2027312326 hasConceptScore W2027312326C2780026642 @default.
• W2027312326 hasConceptScore W2027312326C2780091579 @default.
• W2027312326 hasConceptScore W2027312326C49039625 @default.
• W2027312326 hasConceptScore W2027312326C55493867 @default.
• W2027312326 hasConceptScore W2027312326C71924100 @default.
• W2027312326 hasConceptScore W2027312326C86803240 @default.
• W2027312326 hasIssue "2" @default.
• W2027312326 hasLocation W20273123261 @default.
• W2027312326 hasLocation W20273123262 @default.
• W2027312326 hasOpenAccess W2027312326 @default.
• W2027312326 hasPrimaryLocation W20273123261 @default.

• next