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• W2027322293 endingPage "e85346" @default.
• W2027322293 startingPage "e85346" @default.
• W2027322293 abstract "Metallothionein (MT) has been extensively investigated as a molecular marker of various types of cancer. In spite of the fact that numerous reviews have been published in this field, no meta-analytical approach has been performed. Therefore, results of to-date immunohistochemistry-based studies were summarized using meta-analysis in this review. Web of science, PubMed, Embase and CENTRAL databases were searched (up to April 30, 2013) and the eligibility of individual studies and heterogeneity among the studies was assessed. Random and fixed effects model meta-analysis was employed depending on the heterogeneity, and publication bias was evaluated using funnel plots and Egger's tests. A total of 77 studies were included with 8,015 tissue samples (4,631 cases and 3,384 controls). A significantly positive association between MT staining and tumors (vs. healthy tissues) was observed in head and neck (odds ratio, OR 9.95; 95% CI 5.82–17.03) and ovarian tumors (OR 7.83; 1.09–56.29), and a negative association was ascertained in liver tumors (OR 0.10; 0.03–0.30). No significant associations were identified in breast, colorectal, prostate, thyroid, stomach, bladder, kidney, gallbladder, and uterine cancers and in melanoma. While no associations were identified between MT and tumor staging, a positive association was identified with the tumor grade (OR 1.58; 1.08–2.30). In particular, strong associations were observed in breast, ovarian, uterine and prostate cancers. Borderline significant association of metastatic status and MT staining were determined (OR 1.59; 1.03–2.46), particularly in esophageal cancer. Additionally, a significant association between the patient prognosis and MT staining was also demonstrated (hazard ratio 2.04; 1.47–2.81). However, a high degree of inconsistence was observed in several tumor types, including colorectal, kidney and prostate cancer. Despite the ambiguity in some tumor types, conclusive results are provided in the tumors of head and neck, ovary and liver and in relation to the tumor grade and patient survival." @default.
• W2027322293 created "2016-06-24" @default.
• W2027322293 creator A5006376053 @default.
• W2027322293 creator A5009700689 @default.
• W2027322293 creator A5020780800 @default.
• W2027322293 creator A5029424206 @default.
• W2027322293 creator A5067100284 @default.
• W2027322293 date "2014-01-08" @default.
• W2027322293 modified "2023-09-30" @default.
• W2027322293 title "Metallothionein – Immunohistochemical Cancer Biomarker: A Meta-Analysis" @default.
• W2027322293 cites W1549331050 @default.
• W2027322293 cites W1581718353 @default.
• W2027322293 cites W1761420889 @default.
• W2027322293 cites W1787172519 @default.
• W2027322293 cites W1951470996 @default.
• W2027322293 cites W1964196555 @default.
• W2027322293 cites W1965541279 @default.
• W2027322293 cites W1966540508 @default.
• W2027322293 cites W1972562299 @default.
• W2027322293 cites W1974177801 @default.
• W2027322293 cites W1975592467 @default.
• W2027322293 cites W1977531303 @default.
• W2027322293 cites W1980067834 @default.
• W2027322293 cites W1981909796 @default.
• W2027322293 cites W1984740765 @default.
• W2027322293 cites W1985499095 @default.
• W2027322293 cites W1985967374 @default.
• W2027322293 cites W1988496770 @default.
• W2027322293 cites W1989937700 @default.
• W2027322293 cites W1995025127 @default.
• W2027322293 cites W1995345247 @default.
• W2027322293 cites W1998625450 @default.
• W2027322293 cites W1999489789 @default.
• W2027322293 cites W2000455314 @default.
• W2027322293 cites W2000684747 @default.
• W2027322293 cites W2003882440 @default.
• W2027322293 cites W2008030481 @default.
• W2027322293 cites W2008567439 @default.
• W2027322293 cites W2014000174 @default.
• W2027322293 cites W2016819606 @default.
• W2027322293 cites W2016930530 @default.
• W2027322293 cites W2018788139 @default.
• W2027322293 cites W2021964281 @default.
• W2027322293 cites W2023814887 @default.
• W2027322293 cites W2023949965 @default.
• W2027322293 cites W2024195902 @default.
• W2027322293 cites W2025304110 @default.
• W2027322293 cites W2026962138 @default.
• W2027322293 cites W2028069676 @default.
• W2027322293 cites W2029963008 @default.
• W2027322293 cites W2032094523 @default.
• W2027322293 cites W2034076614 @default.
• W2027322293 cites W2035800017 @default.
• W2027322293 cites W2040976599 @default.
• W2027322293 cites W2041254257 @default.
• W2027322293 cites W2041409468 @default.
• W2027322293 cites W2044147539 @default.
• W2027322293 cites W2045374694 @default.
• W2027322293 cites W2047369394 @default.
• W2027322293 cites W2049626937 @default.
• W2027322293 cites W2050854005 @default.
• W2027322293 cites W2052221663 @default.
• W2027322293 cites W2053862721 @default.
• W2027322293 cites W2055770070 @default.
• W2027322293 cites W2058933521 @default.
• W2027322293 cites W2062304932 @default.
• W2027322293 cites W2064242747 @default.
• W2027322293 cites W2064499068 @default.
• W2027322293 cites W2065448900 @default.
• W2027322293 cites W2066310287 @default.
• W2027322293 cites W2067689492 @default.
• W2027322293 cites W2069613122 @default.
• W2027322293 cites W2074687520 @default.
• W2027322293 cites W2075326357 @default.
• W2027322293 cites W2080645415 @default.
• W2027322293 cites W2081374513 @default.
• W2027322293 cites W2081757386 @default.
• W2027322293 cites W2082787552 @default.
• W2027322293 cites W2084939005 @default.
• W2027322293 cites W2087394178 @default.
• W2027322293 cites W2087933773 @default.
• W2027322293 cites W2090085357 @default.
• W2027322293 cites W2094441246 @default.
• W2027322293 cites W2094629398 @default.
• W2027322293 cites W2095274837 @default.
• W2027322293 cites W2095455591 @default.
• W2027322293 cites W2096202298 @default.
• W2027322293 cites W2099536865 @default.
• W2027322293 cites W2107044618 @default.
• W2027322293 cites W2107328434 @default.
• W2027322293 cites W2107735218 @default.
• W2027322293 cites W2109762957 @default.
• W2027322293 cites W2109887283 @default.
• W2027322293 cites W2110041566 @default.
• W2027322293 cites W2112320195 @default.
• W2027322293 cites W2116235302 @default.
• W2027322293 cites W2118956613 @default.
• W2027322293 cites W2120251017 @default.

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