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• W2027333379 abstract "Objective: We have previously reported a 35-year-old woman where follicle development and estrogen production was restored after transplantation of ovarian tissue in the forearm (Oktay et al. Fertil Steril 2000;74[Suppl 3]:S79). The purpose of this abstract is to report a second case, where for the first time, spontaneous ovulation and menstruation occurred. Design: The patient is a 37 year-old woman who developed a recurrent benign serous cyst in her remaining ovary. After an oophorectomy was performed by the gynecologist, healthy ovarian tissue was harvested from the specimen. Materials/Methods: The tissue was sliced in to 2 × 1 cm strips, and transplanted subcutaneously to the medial aspect of the right forearm. Recombinant FSH 75 iu was injected daily for seven days directly in the grafted tissue to enhance vascularization. In addition, 80 mg/d Aspirin was given for seven days. One week later, the patient was started on hormone replacement. Results: Hormone replacement was discontinued four months after the transplant. Ultrasound monitoring of the forearm revealed an antral follicle development. Two weeks later, the patient had a spontaneous menstruation. During the following menstrual cycle, the patient was monitored with ultrasound and hormone measurements. The patient developed an antral follicle, which reached the maximal diameter of 9-mm after 15 days. On cycle day 16, the patient had a surge (FSH: 40 mIU/mL, LH: 67 mIU/mL). Following the surge, the follicle collapsed, and the progesterone peaked at 12 ng/mL. Estradiol levels peaked at 224 pg/mL, and showed a second peak of 177, seven days after the LH surge. The patient had her menses on cycle day 30. The patient has had two additional menstrual cycles with the duration of 29 and 30 days, at the time of this report. Subjectively, menopausal symptoms resolved and no discomfort was reported at the transplant site. Because the tissue was placed more medially (compared to the previous case), follicle growth was not visible; therefore no cosmetic concerns were raised. Conclusions: Spontaneous ovulation and relatively normal ovarian function resumes after the transplantation of ovarian tissue to the forearm. No significant side effects occur. Ovarian transplantation to the forearm appears to be a useful clinical strategy to preserve ovarian function in patients facing radical surgery or cancer treatment. Supported By: Supported in part by the ASRM-Serono research grant." @default.
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• W2027333379 date "2001-09-01" @default.
• W2027333379 modified "2023-10-16" @default.
• W2027333379 title "Spontaneous ovulation and menstruation following ovarian transplantation to the forearm." @default.
• W2027333379 doi "https://doi.org/10.1016/s0015-0282(01)02230-0" @default.
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