FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027342417> ?p ?o ?g. }

• W2027342417 endingPage "623" @default.
• W2027342417 startingPage "613" @default.
• W2027342417 abstract "For the development of calix[4]arene-based radiotherapeutic agents, the conjugation to biomolecules and immunogenicity in mice of potential 225Ac3+-chelating calix[4]arenes were studied. A calix[4]arene triethyl ester isothiocyanate and a bis(calix[4]arene) hexacarboxylic acid, containing a masked thiol functionality, were used in conjugation experiments to a mouse monoclonal antibody and serum albumins. All characterization techniques indicate that only the calix[4]arene carboxylic acid is successfully conjugated to the biomolecules. The immunoreactivity of the conjugates is not impaired when up to 6 equiv of calixarene are bound to the monoclonal antibody. Animal tests indicated that the immunogenicity toward the calix[4]arene is strongly influenced by the nature of the carrier, the dosage, and the injection method. No immune response occurred when a homologous carrier was used or when a heterologous carrier was applied at a dosage of 10 μg per immunization via intravenous injection. Under all other conditions, the presence of antibodies directed against the calix[4]arene was demonstrated. Thus, for the application in radioimmunotherapy, the conjugation of a calix[4]arene to a humanized antibody will probably not lead to an immune response, and the immunoreactivity will not be disturbed." @default.
• W2027342417 created "2016-06-24" @default.
• W2027342417 creator A5045120040 @default.
• W2027342417 creator A5048654956 @default.
• W2027342417 creator A5050376133 @default.
• W2027342417 creator A5054594631 @default.
• W2027342417 creator A5064501351 @default.
• W2027342417 date "1999-06-23" @default.
• W2027342417 modified "2023-10-18" @default.
• W2027342417 title "Conjugation, Immunoreactivity, and Immunogenicity of Calix[4]arenes; Model Study to Potential Calix[4]arene-Based Ac³⁺ Chelators" @default.
• W2027342417 cites W1500651769 @default.
• W2027342417 cites W1773975057 @default.
• W2027342417 cites W1966658039 @default.
• W2027342417 cites W1984430708 @default.
• W2027342417 cites W1988013402 @default.
• W2027342417 cites W2008986800 @default.
• W2027342417 cites W2021043282 @default.
• W2027342417 cites W2064002133 @default.
• W2027342417 cites W2067073802 @default.
• W2027342417 cites W2086892273 @default.
• W2027342417 cites W2090503393 @default.
• W2027342417 cites W2094250974 @default.
• W2027342417 cites W2105422162 @default.
• W2027342417 cites W2110642296 @default.
• W2027342417 cites W2119886027 @default.
• W2027342417 cites W2123555262 @default.
• W2027342417 cites W2126578481 @default.
• W2027342417 cites W2170341574 @default.
• W2027342417 cites W2900251875 @default.
• W2027342417 cites W7425409 @default.
• W2027342417 doi "https://doi.org/10.1021/bc9801474" @default.
• W2027342417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10411459" @default.
• W2027342417 hasPublicationYear "1999" @default.
• W2027342417 type Work @default.
• W2027342417 sameAs 2027342417 @default.
• W2027342417 citedByCount "36" @default.
• W2027342417 countsByYear W20273424172012 @default.
• W2027342417 countsByYear W20273424172013 @default.
• W2027342417 countsByYear W20273424172015 @default.
• W2027342417 countsByYear W20273424172018 @default.
• W2027342417 countsByYear W20273424172020 @default.
• W2027342417 countsByYear W20273424172023 @default.
• W2027342417 crossrefType "journal-article" @default.
• W2027342417 hasAuthorship W2027342417A5045120040 @default.
• W2027342417 hasAuthorship W2027342417A5048654956 @default.
• W2027342417 hasAuthorship W2027342417A5050376133 @default.
• W2027342417 hasAuthorship W2027342417A5054594631 @default.
• W2027342417 hasAuthorship W2027342417A5064501351 @default.
• W2027342417 hasBestOaLocation W20273424172 @default.
• W2027342417 hasConcept C112613896 @default.
• W2027342417 hasConcept C134306372 @default.
• W2027342417 hasConcept C159654299 @default.
• W2027342417 hasConcept C178790620 @default.
• W2027342417 hasConcept C185592680 @default.
• W2027342417 hasConcept C197336794 @default.
• W2027342417 hasConcept C197404232 @default.
• W2027342417 hasConcept C203014093 @default.
• W2027342417 hasConcept C2780868878 @default.
• W2027342417 hasConcept C32909587 @default.
• W2027342417 hasConcept C33923547 @default.
• W2027342417 hasConcept C49853544 @default.
• W2027342417 hasConcept C521977710 @default.
• W2027342417 hasConcept C542903549 @default.
• W2027342417 hasConcept C55493867 @default.
• W2027342417 hasConcept C71240020 @default.
• W2027342417 hasConcept C83263248 @default.
• W2027342417 hasConcept C86803240 @default.
• W2027342417 hasConceptScore W2027342417C112613896 @default.
• W2027342417 hasConceptScore W2027342417C134306372 @default.
• W2027342417 hasConceptScore W2027342417C159654299 @default.
• W2027342417 hasConceptScore W2027342417C178790620 @default.
• W2027342417 hasConceptScore W2027342417C185592680 @default.
• W2027342417 hasConceptScore W2027342417C197336794 @default.
• W2027342417 hasConceptScore W2027342417C197404232 @default.
• W2027342417 hasConceptScore W2027342417C203014093 @default.
• W2027342417 hasConceptScore W2027342417C2780868878 @default.
• W2027342417 hasConceptScore W2027342417C32909587 @default.
• W2027342417 hasConceptScore W2027342417C33923547 @default.
• W2027342417 hasConceptScore W2027342417C49853544 @default.
• W2027342417 hasConceptScore W2027342417C521977710 @default.
• W2027342417 hasConceptScore W2027342417C542903549 @default.
• W2027342417 hasConceptScore W2027342417C55493867 @default.
• W2027342417 hasConceptScore W2027342417C71240020 @default.
• W2027342417 hasConceptScore W2027342417C83263248 @default.
• W2027342417 hasConceptScore W2027342417C86803240 @default.
• W2027342417 hasIssue "4" @default.
• W2027342417 hasLocation W20273424171 @default.
• W2027342417 hasLocation W20273424172 @default.
• W2027342417 hasLocation W20273424173 @default.
• W2027342417 hasOpenAccess W2027342417 @default.
• W2027342417 hasPrimaryLocation W20273424171 @default.
• W2027342417 hasRelatedWork W1591820460 @default.
• W2027342417 hasRelatedWork W1899411185 @default.
• W2027342417 hasRelatedWork W195682249 @default.
• W2027342417 hasRelatedWork W2258260565 @default.
• W2027342417 hasRelatedWork W2389619020 @default.
• W2027342417 hasRelatedWork W2419379701 @default.
• W2027342417 hasRelatedWork W2949098585 @default.

• next