Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027358618> ?p ?o ?g. }
- W2027358618 endingPage "1197" @default.
- W2027358618 startingPage "1189" @default.
- W2027358618 abstract "Abstract BACKGROUND The influence of PSA kinetics on the outcome of metastatic prostate cancer after androgen deprivation therapy (ADT) is not well understood. We evaluated the prognostic significance of PSA nadir and time to PSA nadir as well as their potential interactive effect on the progression of disease after ADT. METHODS A total of 650 men with advanced or metastatic prostate cancer treated with ADT were studied. The prognostic significance of PSA nadir and time to PSA nadir on disease progression were analyzed using Kaplan–Meier analysis and the Cox regression model. RESULTS We found that both PSA nadir and time to PSA nadir were independent and significant predictors of disease progression. Patients with higher PSA nadir (≥0.2 ng/ml) and shorter time to PSA nadir (<10 months) had significant shorter time to disease progression after adjusting for other covariates. The combined analyses showed a potential synergistic effect of these two variables on disease progression. Patient with higher PSA nadir and shorter time to PSA nadir had significantly higher risk for disease progression compared to those with lower PSA nadir and longer time to PSA nadir (Hazard Ratios (HR) = 3.11, P < 0.001). CONCLUSIONS We concluded that both PSA nadir and time to PSA nadir are significant predictors of disease progression for prostate cancer patients receiving ADT. Prostate 71:1189–1197, 2011. © 2011 Wiley‐Liss, Inc." @default.
- W2027358618 created "2016-06-24" @default.
- W2027358618 creator A5030951075 @default.
- W2027358618 creator A5041679786 @default.
- W2027358618 creator A5045311583 @default.
- W2027358618 creator A5050179357 @default.
- W2027358618 creator A5052504518 @default.
- W2027358618 creator A5054033654 @default.
- W2027358618 creator A5056912122 @default.
- W2027358618 creator A5058663662 @default.
- W2027358618 creator A5069371197 @default.
- W2027358618 date "2011-01-12" @default.
- W2027358618 modified "2023-10-17" @default.
- W2027358618 title "Impact of prostate-specific antigen (PSA) nadir and time to PSA nadir on disease progression in prostate cancer treated with androgen-deprivation therapy" @default.
- W2027358618 cites W122252942 @default.
- W2027358618 cites W1542345927 @default.
- W2027358618 cites W1896816349 @default.
- W2027358618 cites W1976677474 @default.
- W2027358618 cites W1994893199 @default.
- W2027358618 cites W1995284087 @default.
- W2027358618 cites W2003985632 @default.
- W2027358618 cites W2009226524 @default.
- W2027358618 cites W2014145760 @default.
- W2027358618 cites W2022085298 @default.
- W2027358618 cites W2024304133 @default.
- W2027358618 cites W2026094546 @default.
- W2027358618 cites W2037733927 @default.
- W2027358618 cites W2074544671 @default.
- W2027358618 cites W2100465174 @default.
- W2027358618 cites W2103090668 @default.
- W2027358618 cites W2111238914 @default.
- W2027358618 cites W2112304044 @default.
- W2027358618 cites W2112689533 @default.
- W2027358618 cites W2113092779 @default.
- W2027358618 cites W2117792530 @default.
- W2027358618 cites W2118722809 @default.
- W2027358618 cites W2123230901 @default.
- W2027358618 cites W2132315278 @default.
- W2027358618 cites W2139871731 @default.
- W2027358618 cites W2145608595 @default.
- W2027358618 cites W2148180201 @default.
- W2027358618 cites W2149056940 @default.
- W2027358618 cites W2152411252 @default.
- W2027358618 cites W2152715017 @default.
- W2027358618 cites W2154893263 @default.
- W2027358618 cites W2160064859 @default.
- W2027358618 cites W2161282696 @default.
- W2027358618 cites W2161637485 @default.
- W2027358618 cites W2165564512 @default.
- W2027358618 cites W2167331614 @default.
- W2027358618 cites W2167869791 @default.
- W2027358618 cites W2171724045 @default.
- W2027358618 cites W2766384743 @default.
- W2027358618 cites W4321317559 @default.
- W2027358618 doi "https://doi.org/10.1002/pros.21334" @default.
- W2027358618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21656829" @default.
- W2027358618 hasPublicationYear "2011" @default.
- W2027358618 type Work @default.
- W2027358618 sameAs 2027358618 @default.
- W2027358618 citedByCount "50" @default.
- W2027358618 countsByYear W20273586182012 @default.
- W2027358618 countsByYear W20273586182013 @default.
- W2027358618 countsByYear W20273586182014 @default.
- W2027358618 countsByYear W20273586182015 @default.
- W2027358618 countsByYear W20273586182016 @default.
- W2027358618 countsByYear W20273586182017 @default.
- W2027358618 countsByYear W20273586182018 @default.
- W2027358618 countsByYear W20273586182019 @default.
- W2027358618 countsByYear W20273586182020 @default.
- W2027358618 countsByYear W20273586182021 @default.
- W2027358618 countsByYear W20273586182022 @default.
- W2027358618 countsByYear W20273586182023 @default.
- W2027358618 crossrefType "journal-article" @default.
- W2027358618 hasAuthorship W2027358618A5030951075 @default.
- W2027358618 hasAuthorship W2027358618A5041679786 @default.
- W2027358618 hasAuthorship W2027358618A5045311583 @default.
- W2027358618 hasAuthorship W2027358618A5050179357 @default.
- W2027358618 hasAuthorship W2027358618A5052504518 @default.
- W2027358618 hasAuthorship W2027358618A5054033654 @default.
- W2027358618 hasAuthorship W2027358618A5056912122 @default.
- W2027358618 hasAuthorship W2027358618A5058663662 @default.
- W2027358618 hasAuthorship W2027358618A5069371197 @default.
- W2027358618 hasConcept C121608353 @default.
- W2027358618 hasConcept C126322002 @default.
- W2027358618 hasConcept C126894567 @default.
- W2027358618 hasConcept C127413603 @default.
- W2027358618 hasConcept C143998085 @default.
- W2027358618 hasConcept C146978453 @default.
- W2027358618 hasConcept C19269812 @default.
- W2027358618 hasConcept C2776235491 @default.
- W2027358618 hasConcept C2777899217 @default.
- W2027358618 hasConcept C2780192828 @default.
- W2027358618 hasConcept C2781406297 @default.
- W2027358618 hasConcept C50382708 @default.
- W2027358618 hasConcept C71924100 @default.
- W2027358618 hasConcept C88575799 @default.
- W2027358618 hasConceptScore W2027358618C121608353 @default.
- W2027358618 hasConceptScore W2027358618C126322002 @default.