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- W2027360047 endingPage "588" @default.
- W2027360047 startingPage "573" @default.
- W2027360047 abstract "Introduction: Combination antiretroviral therapy has enabled HIV-infected persons to reach older ages in high numbers. Hepatic and renal changes that normally occur with advancing age occur earlier and with higher incidence in HIV-infected individuals. A limited number of prospective controlled studies have demonstrated small reductions (17 to 41%) in lopinavir, atazanavir and lamivudine clearance in older versus younger adults. A much larger number of retrospective studies in adults (age range ∼ 20 to 60 years), including all antiretroviral drugs, have evaluated age as a covariate for pharmacokinetics. Most studies did not detect substantial associations between drug exposures and age. Areas covered: This review summarizes antiretroviral drug pharmacokinetics in older persons. The authors review articles from PubMed (search terms: elderly, antiretroviral, pharmacokinetics) in addition to the bibliographies of those selected. Expert opinion: The evidence to date does not support major pharmacokinetic changes in adults between ∼ 20 and 60 years of age. However, additional prospective, well-controlled studies are needed in more persons > 60 years, including those with frailty and comorbidities, with assessment of unbound drug clearance, and incorporation of adherence, pharmacogenetics and concomitant medications. Until then, guidelines for drug–drug interactions and dosing in renal and hepatic impairment should be followed in older HIV-infected individuals." @default.
- W2027360047 created "2016-06-24" @default.
- W2027360047 creator A5007571350 @default.
- W2027360047 creator A5015808791 @default.
- W2027360047 creator A5054571824 @default.
- W2027360047 date "2013-03-20" @default.
- W2027360047 modified "2023-10-02" @default.
- W2027360047 title "<b>Clinical pharmacokinetics of antiretroviral drugs in older persons</b>" @default.
- W2027360047 cites W1482153588 @default.
- W2027360047 cites W1812712408 @default.
- W2027360047 cites W1940770670 @default.
- W2027360047 cites W1963635937 @default.
- W2027360047 cites W1967002017 @default.
- W2027360047 cites W1969982801 @default.
- W2027360047 cites W1971773192 @default.
- W2027360047 cites W1972424763 @default.
- W2027360047 cites W1974423393 @default.
- W2027360047 cites W1975960962 @default.
- W2027360047 cites W1980162669 @default.
- W2027360047 cites W1980720468 @default.
- W2027360047 cites W1981458531 @default.
- W2027360047 cites W1984117544 @default.
- W2027360047 cites W1984189311 @default.
- W2027360047 cites W1988545739 @default.
- W2027360047 cites W1994626354 @default.
- W2027360047 cites W1997066747 @default.
- W2027360047 cites W1998202799 @default.
- W2027360047 cites W1999160932 @default.
- W2027360047 cites W1999487909 @default.
- W2027360047 cites W2005240331 @default.
- W2027360047 cites W2009054978 @default.
- W2027360047 cites W2010335509 @default.
- W2027360047 cites W2011178237 @default.
- W2027360047 cites W2011720238 @default.
- W2027360047 cites W2012459259 @default.
- W2027360047 cites W2012886010 @default.
- W2027360047 cites W2014863810 @default.
- W2027360047 cites W2015054602 @default.
- W2027360047 cites W2020188944 @default.
- W2027360047 cites W2024944903 @default.
- W2027360047 cites W2027416226 @default.
- W2027360047 cites W2027772168 @default.
- W2027360047 cites W2027974475 @default.
- W2027360047 cites W2028042907 @default.
- W2027360047 cites W2030667890 @default.
- W2027360047 cites W2032074457 @default.
- W2027360047 cites W2032959558 @default.
- W2027360047 cites W2034599566 @default.
- W2027360047 cites W2035462276 @default.
- W2027360047 cites W2041871645 @default.
- W2027360047 cites W2043271609 @default.
- W2027360047 cites W2045229224 @default.
- W2027360047 cites W2046108896 @default.
- W2027360047 cites W2046479724 @default.
- W2027360047 cites W2047120948 @default.
- W2027360047 cites W2047486559 @default.
- W2027360047 cites W2050103286 @default.
- W2027360047 cites W2053029032 @default.
- W2027360047 cites W2056805447 @default.
- W2027360047 cites W2058435599 @default.
- W2027360047 cites W2059158540 @default.
- W2027360047 cites W2062803628 @default.
- W2027360047 cites W2063712486 @default.
- W2027360047 cites W2064068523 @default.
- W2027360047 cites W2064883756 @default.
- W2027360047 cites W2072661867 @default.
- W2027360047 cites W2073232204 @default.
- W2027360047 cites W2075051244 @default.
- W2027360047 cites W2078566245 @default.
- W2027360047 cites W2079161400 @default.
- W2027360047 cites W2079485551 @default.
- W2027360047 cites W2080544294 @default.
- W2027360047 cites W2080729653 @default.
- W2027360047 cites W2080861496 @default.
- W2027360047 cites W2081243063 @default.
- W2027360047 cites W2081751675 @default.
- W2027360047 cites W2081752205 @default.
- W2027360047 cites W2082099226 @default.
- W2027360047 cites W2082406198 @default.
- W2027360047 cites W2085199878 @default.
- W2027360047 cites W2087828488 @default.
- W2027360047 cites W2088573595 @default.
- W2027360047 cites W2090905584 @default.
- W2027360047 cites W2092037586 @default.
- W2027360047 cites W2093044657 @default.
- W2027360047 cites W2095442537 @default.
- W2027360047 cites W2095748010 @default.
- W2027360047 cites W2096650127 @default.
- W2027360047 cites W2100948308 @default.
- W2027360047 cites W2101191281 @default.
- W2027360047 cites W2102046578 @default.
- W2027360047 cites W2107869736 @default.
- W2027360047 cites W2108598052 @default.
- W2027360047 cites W2112129837 @default.
- W2027360047 cites W2114549408 @default.
- W2027360047 cites W2115888573 @default.
- W2027360047 cites W2116046162 @default.
- W2027360047 cites W2116125253 @default.