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- W2027377609 abstract "Serum β-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL6 < BALBc, DBA2, ICR < SENCAR, AHe. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroids, which in turn reflects the endogenous level of androgens. Dietary calcium d-glucarate, an in vivo β-glucuronidase inhibitor, reduced the steady state level of both β-glucuronidase and 17-ketosteroid excretion in the highly susceptible AHe and SENCAR strains to that of strains known to be resistant to chemical carcinogenesis. Sensitivity of the AHe strain is significantly reduced by dietary calcium glucarate, which is shown to inhibit DNA binding and the induction of pulmonary adenomas by benzo[a]pyrene." @default.
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- W2027377609 date "1986-10-01" @default.
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- W2027377609 title "Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis" @default.
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- W2027377609 doi "https://doi.org/10.1016/0304-3835(86)90098-4" @default.
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