Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027380064> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2027380064 endingPage "297" @default.
- W2027380064 startingPage "291" @default.
- W2027380064 abstract "The genetic effect of the cytostatic trichlormethine hydrochloride (TS-160 Spofa) was assessed after a 1-week administration using the dominant lethal mutation test (DLM) and the sperm abnormality test. The dosage was 0.5 mg/kg for 7 consecutive days, an equivalent of the human therapeutic dosage. Simultaneously, the cytostatic's direct toxic effect on male sex organs was assessed. TS-160 carries a genetic risk for the postmeiotic stages of spermatogenesis (DLM) and is responsible for interference in the morphology of sperm heads through its action on spermatocytes. The toxic effects of TS-160 were found to influence the body weight of mice (days 4-25 after administration), to reduce the relative weight of the testes (days 18-25 after administration), to damage spermatogenesis in the seminiferous tubules (spermatids), to be responsible for an appearance of multinucleate cells in the epididymides, and for an increased rate of abnormality of the heads of fully mature spermatozoa. Our findings stress the need to separate the cytotoxic effects from genetic effects so as to avoid false positives, especially in the test for head abnormalities, and also in the assessment of the fertility of male animals or fertilization of females mated with treated males." @default.
- W2027380064 created "2016-06-24" @default.
- W2027380064 creator A5003494145 @default.
- W2027380064 creator A5084275876 @default.
- W2027380064 date "1992-04-01" @default.
- W2027380064 modified "2023-10-08" @default.
- W2027380064 title "Trichlormethine hydrochloride and correlation of its mutagenic and toxic effects on male germ cells in mice" @default.
- W2027380064 cites W1526749473 @default.
- W2027380064 cites W1631327356 @default.
- W2027380064 cites W1970651721 @default.
- W2027380064 cites W1986070516 @default.
- W2027380064 cites W1996973272 @default.
- W2027380064 cites W2016759352 @default.
- W2027380064 cites W2055923914 @default.
- W2027380064 cites W2064446194 @default.
- W2027380064 cites W2082756386 @default.
- W2027380064 cites W2165195418 @default.
- W2027380064 doi "https://doi.org/10.1016/0027-5107(92)90196-9" @default.
- W2027380064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1373838" @default.
- W2027380064 hasPublicationYear "1992" @default.
- W2027380064 type Work @default.
- W2027380064 sameAs 2027380064 @default.
- W2027380064 citedByCount "5" @default.
- W2027380064 countsByYear W20273800642012 @default.
- W2027380064 crossrefType "journal-article" @default.
- W2027380064 hasAuthorship W2027380064A5003494145 @default.
- W2027380064 hasAuthorship W2027380064A5084275876 @default.
- W2027380064 hasConcept C118552586 @default.
- W2027380064 hasConcept C123765429 @default.
- W2027380064 hasConcept C126322002 @default.
- W2027380064 hasConcept C134018914 @default.
- W2027380064 hasConcept C16685009 @default.
- W2027380064 hasConcept C2776687438 @default.
- W2027380064 hasConcept C2781087480 @default.
- W2027380064 hasConcept C33070731 @default.
- W2027380064 hasConcept C42407357 @default.
- W2027380064 hasConcept C50965678 @default.
- W2027380064 hasConcept C54355233 @default.
- W2027380064 hasConcept C71924100 @default.
- W2027380064 hasConcept C86803240 @default.
- W2027380064 hasConceptScore W2027380064C118552586 @default.
- W2027380064 hasConceptScore W2027380064C123765429 @default.
- W2027380064 hasConceptScore W2027380064C126322002 @default.
- W2027380064 hasConceptScore W2027380064C134018914 @default.
- W2027380064 hasConceptScore W2027380064C16685009 @default.
- W2027380064 hasConceptScore W2027380064C2776687438 @default.
- W2027380064 hasConceptScore W2027380064C2781087480 @default.
- W2027380064 hasConceptScore W2027380064C33070731 @default.
- W2027380064 hasConceptScore W2027380064C42407357 @default.
- W2027380064 hasConceptScore W2027380064C50965678 @default.
- W2027380064 hasConceptScore W2027380064C54355233 @default.
- W2027380064 hasConceptScore W2027380064C71924100 @default.
- W2027380064 hasConceptScore W2027380064C86803240 @default.
- W2027380064 hasIssue "2" @default.
- W2027380064 hasLocation W20273800641 @default.
- W2027380064 hasLocation W20273800642 @default.
- W2027380064 hasOpenAccess W2027380064 @default.
- W2027380064 hasPrimaryLocation W20273800641 @default.
- W2027380064 hasRelatedWork W1984230762 @default.
- W2027380064 hasRelatedWork W2021310223 @default.
- W2027380064 hasRelatedWork W2024683308 @default.
- W2027380064 hasRelatedWork W2047695780 @default.
- W2027380064 hasRelatedWork W2049950626 @default.
- W2027380064 hasRelatedWork W2070214996 @default.
- W2027380064 hasRelatedWork W2368753383 @default.
- W2027380064 hasRelatedWork W2438813999 @default.
- W2027380064 hasRelatedWork W3146739576 @default.
- W2027380064 hasRelatedWork W4323286707 @default.
- W2027380064 hasVolume "266" @default.
- W2027380064 isParatext "false" @default.
- W2027380064 isRetracted "false" @default.
- W2027380064 magId "2027380064" @default.
- W2027380064 workType "article" @default.