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• W2027384914 startingPage "7224" @default.
• W2027384914 abstract "We have prepared oligonucleotides containing the novel base analogue 2'-aminoethoxy,5-propargylamino-U in place of thymidine and examined their ability to form intermolecular and intramolecular triple helices by DNase I footprinting and thermal melting studies. The results were compared with those for oligonucleotides containing 5-propargylamino-dU and 2'-aminoethoxy-T. We find that the bis-substituted derivative produces a large increase in triplex stability, much greater than that produced by either of the monosubstituted analogues, which are roughly equipotent with each other. Intermolecular triplexes with 9-mer oligonucleotides containing three or four base modifications generate footprints at submicromolar concentrations even at pH 7.5, in contrast to the unmodified oligonucleotide, which failed to produce a footprint at pH 5.0, even at 30 microM. UV- and fluorescence melting studies with intramolecular triplexes confirmed that the bis-modified base produces a much greater increase in T(m) than either modification alone." @default.
• W2027384914 created "2016-06-24" @default.
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• W2027384914 date "2002-05-17" @default.
• W2027384914 modified "2023-10-18" @default.
• W2027384914 title "Stable DNA Triple Helix Formation Using Oligonucleotides Containing 2‘-Aminoethoxy,5-propargylamino-U" @default.
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• W2027384914 doi "https://doi.org/10.1021/bi020164n" @default.
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