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- W2027389347 abstract "A rising awareness of natural products with hallucinogenic properties and their potential for abuse in recent years has led to the wider introduction of traditionally used medicines to the Western world. Among them are three plant extracts that present various medicinal properties. Extracts from Salvia divinorum (Diviner's sage), Mitragyna speciosa (Kratom), and Banisteriopsis caapi and Psychotria viridis (Ayahuasca) have gained interest both among public health and legal officials due to increased reports of their use for recreational purposes. There are confirmed active ingredients in each of these extracts that have been investigated further in vitro and in vivo as well as in human trials for both their potential medicinal benefits and their abuse potential. Salvinorin A from S. divinorum presents as a nonnitrogenous kappa opioid receptor agonist with potential applications for inflammation, pain, and depressive disorders. Mitragynine from M. speciosa has shown both opioid receptor and sympathomimetic activities and may provide applications in the treatment of pain and a variety of CNS disorders. N,N-Dimethyltryptamine from P. viridis, in combination with monoamine oxidase inhibitors from B. caapi, has long been useful in treating substance use disorders as well as depressive and anxiety afflictions. This chapter provides an overview of the mechanisms of action, structure-activity relationship, and current knowledge of the potential clinical applications of each extract and their respective active constituents and derivatives." @default.
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- W2027389347 date "2005-08-01" @default.
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- W2027389347 title "Focus on Molecules: the Sigma-1 Receptor" @default.
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- W2027389347 doi "https://doi.org/10.1016/j.exer.2005.06.008" @default.
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