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- W2027398041 abstract "Glutamine has been shown to be of critical importance for various cell functions (1-5). A number of mammalian cells in culture including fibroblasts (6), HeLa cells (7) and other tumour cell lines exhibit a positive correlation between cell growth and glutamine support. Zetterberg (6) demonstrated the dependence on glutamine of DNA/ RNA replication and cell multiplication in fibroblasts. In non-proliferating cells, i.e. primary cell cultures, the importance of glutamine as an essential substrate has not yet been established. However, studies on cell differentiation are contradictory: Beaulieu (8) reported a permissive effect of glutamine on differentiation of foetal small intestine, whereas in Viallard’s study differentiation of a human colon cancer cell line occurred only in the absence of glutamine (9). Under physiological conditions, the small intestine exhibits a high net glutamine utilisation in many species, including man, exceeding that of all other organs measured (for review, see (10,ll)). Apart from its relevance as a metabolic fuel for intestinal epithelial cells, only few data are available on the glutamine-dependence of characteristic enterocyte functions (12-15). The experimental use of glutaminase as an anti-neoplastic agent resulted in a decrease of serum glutamine to undetectable levels and acute necrotising colitis as a severe side-effect (16). Conversely, glutamine exerted a beneficial effect on intestinal mucosa after TPN induced atrophy (17, 18) or methotrexate induced enterocolitis (19). We therefore investigated the glutamine dependence of various intestinal cell functions in shortterm cell cultures of freshly isolated differentiated enterocytes of adult rats." @default.
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- W2027398041 date "1991-04-01" @default.
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- W2027398041 title "Glutamine-dependence of rat enterocyte functions as assessed in cell cultures" @default.
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- W2027398041 doi "https://doi.org/10.1016/0261-5614(91)90099-x" @default.
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