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- W2027405672 abstract "It has been shown that by a simple procedure the variant specific protective antigen can be isolated from both T. gambiense and T. equiperdum. The protection afforded mice by this antigen is relatively long term and a high percentage of mice has complete protection. It has been suggested that the antigens are highly antigenic and although antigenically unique for each relapse strain, they have one or more common physical characteristic. It is therefore hypothesized that a multivalent vaccine might be prepared by similar procedures for protection against trypanosomiasis. The results have also suggested that the properties of agglutination and protection are due to two different antigens presumably located in the surface coat. These two variant specific antigens are further hypothesized to act as primary stimuli, resulting in the production of 19S antibodies. These were shown to protect animals passively against a challenge infection and appear to be correlated with the trypanosome relapse. It is therefore hypothesized that a 19S antibody is at least partially responsible for the relapse observed in infected rabbits." @default.
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- W2027405672 date "1972-02-01" @default.
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- W2027405672 title "Trypanosoma gambiense and T. equiperdum: Characterization of variant specific antigens" @default.
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- W2027405672 doi "https://doi.org/10.1016/0014-4894(72)90052-5" @default.
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