FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027422185> ?p ?o ?g. }

• W2027422185 endingPage "197" @default.
• W2027422185 startingPage "192" @default.
• W2027422185 abstract "Vascular smooth muscle cell (SMC) migration, proliferation and extracellular matrix protein production are key steps in the formation of intimal hyperplasia, a process that leads to failure of vascular reconstructions. Protein kinase C (PKC) may be involved in all 3 cellular events. PKC consists of a family of 11 isotypes, 8 of which we have identified in human vascular SMCs. In this study we evaluate the role of PKCalpha as a second messenger for proliferation, migration and fibronectin production induced by human saphenous vein SMCs.DNA synthesis was evaluated by using (3)H-thymidine incorporation. Mitogen-activated protein kinase (MAP-K) activation was quantified by Western blotting with an antibody to its phosphorylated substrate, Elk-1. Chemotaxis was evaluated by using a microchemotaxis chamber. SMC fibronectin was measured by Western blotting. For all experiments, PKCalpha was blocked with a selective inhibitor, Gö6976.Gö6976, at concentrations that allow selective inhibition of PKCalpha, inhibited platelet-derived growth factor-stimulated SMC proliferation and MAP-K activation by 30% to 40% and 30% to 60%, respectively. SMC chemotaxis was stimulated approximately 2-fold by the PKCalpha inhibitor. Neither basal nor transforming growth factor-betaI induced fibronectin production was affected by Gö6976.Our data suggest that PKCalpha is a positive mediator of SMC proliferation and MAP-K activity, a negative regulator of migration and has no effect on SMC fibronectin production. These data suggest that modulating activities of specific PKC isotypes might be useful in both the study and control of intimal hyperplasia." @default.
• W2027422185 created "2016-06-24" @default.
• W2027422185 creator A5012140656 @default.
• W2027422185 creator A5033129591 @default.
• W2027422185 creator A5051220005 @default.
• W2027422185 creator A5070538182 @default.
• W2027422185 date "2000-08-01" @default.
• W2027422185 modified "2023-09-23" @default.
• W2027422185 title "The effect of protein kinase C and its alpha subtype on human vascular smooth muscle cell proliferation, migration and fibronectin production" @default.
• W2027422185 cites W1520548964 @default.
• W2027422185 cites W1567873484 @default.
• W2027422185 cites W1641731911 @default.
• W2027422185 cites W1968232501 @default.
• W2027422185 cites W1968820837 @default.
• W2027422185 cites W1983039493 @default.
• W2027422185 cites W1990996074 @default.
• W2027422185 cites W1993751209 @default.
• W2027422185 cites W1997447547 @default.
• W2027422185 cites W2003135311 @default.
• W2027422185 cites W2010576837 @default.
• W2027422185 cites W2018801742 @default.
• W2027422185 cites W2031334877 @default.
• W2027422185 cites W2040816657 @default.
• W2027422185 cites W2041797033 @default.
• W2027422185 cites W2057805062 @default.
• W2027422185 cites W2079405800 @default.
• W2027422185 cites W2086524338 @default.
• W2027422185 cites W2103284132 @default.
• W2027422185 cites W2106898231 @default.
• W2027422185 cites W2152271058 @default.
• W2027422185 cites W2161004234 @default.
• W2027422185 doi "https://doi.org/10.1067/msy.2000.108062" @default.
• W2027422185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10922991" @default.
• W2027422185 hasPublicationYear "2000" @default.
• W2027422185 type Work @default.
• W2027422185 sameAs 2027422185 @default.
• W2027422185 citedByCount "27" @default.
• W2027422185 countsByYear W20274221852012 @default.
• W2027422185 countsByYear W20274221852014 @default.
• W2027422185 countsByYear W20274221852017 @default.
• W2027422185 countsByYear W20274221852018 @default.
• W2027422185 countsByYear W20274221852021 @default.
• W2027422185 crossrefType "journal-article" @default.
• W2027422185 hasAuthorship W2027422185A5012140656 @default.
• W2027422185 hasAuthorship W2027422185A5033129591 @default.
• W2027422185 hasAuthorship W2027422185A5051220005 @default.
• W2027422185 hasAuthorship W2027422185A5070538182 @default.
• W2027422185 hasConcept C11960822 @default.
• W2027422185 hasConcept C134018914 @default.
• W2027422185 hasConcept C137738243 @default.
• W2027422185 hasConcept C1491633281 @default.
• W2027422185 hasConcept C153911025 @default.
• W2027422185 hasConcept C189165786 @default.
• W2027422185 hasConcept C195794163 @default.
• W2027422185 hasConcept C2779395532 @default.
• W2027422185 hasConcept C2779751240 @default.
• W2027422185 hasConcept C2992686903 @default.
• W2027422185 hasConcept C55493867 @default.
• W2027422185 hasConcept C62112901 @default.
• W2027422185 hasConcept C71924100 @default.
• W2027422185 hasConcept C86492073 @default.
• W2027422185 hasConcept C86803240 @default.
• W2027422185 hasConcept C95444343 @default.
• W2027422185 hasConcept C97029542 @default.
• W2027422185 hasConceptScore W2027422185C11960822 @default.
• W2027422185 hasConceptScore W2027422185C134018914 @default.
• W2027422185 hasConceptScore W2027422185C137738243 @default.
• W2027422185 hasConceptScore W2027422185C1491633281 @default.
• W2027422185 hasConceptScore W2027422185C153911025 @default.
• W2027422185 hasConceptScore W2027422185C189165786 @default.
• W2027422185 hasConceptScore W2027422185C195794163 @default.
• W2027422185 hasConceptScore W2027422185C2779395532 @default.
• W2027422185 hasConceptScore W2027422185C2779751240 @default.
• W2027422185 hasConceptScore W2027422185C2992686903 @default.
• W2027422185 hasConceptScore W2027422185C55493867 @default.
• W2027422185 hasConceptScore W2027422185C62112901 @default.
• W2027422185 hasConceptScore W2027422185C71924100 @default.
• W2027422185 hasConceptScore W2027422185C86492073 @default.
• W2027422185 hasConceptScore W2027422185C86803240 @default.
• W2027422185 hasConceptScore W2027422185C95444343 @default.
• W2027422185 hasConceptScore W2027422185C97029542 @default.
• W2027422185 hasIssue "2" @default.
• W2027422185 hasLocation W20274221851 @default.
• W2027422185 hasLocation W20274221852 @default.
• W2027422185 hasOpenAccess W2027422185 @default.
• W2027422185 hasPrimaryLocation W20274221851 @default.
• W2027422185 hasRelatedWork W1974377564 @default.
• W2027422185 hasRelatedWork W1993602817 @default.
• W2027422185 hasRelatedWork W1995698795 @default.
• W2027422185 hasRelatedWork W2034939167 @default.
• W2027422185 hasRelatedWork W2041178877 @default.
• W2027422185 hasRelatedWork W2064487804 @default.
• W2027422185 hasRelatedWork W2106761248 @default.
• W2027422185 hasRelatedWork W2330163142 @default.
• W2027422185 hasRelatedWork W3013012450 @default.
• W2027422185 hasRelatedWork W4386001695 @default.
• W2027422185 hasVolume "128" @default.
• W2027422185 isParatext "false" @default.

• next