Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027423193> ?p ?o ?g. }
- W2027423193 endingPage "1092" @default.
- W2027423193 startingPage "1081" @default.
- W2027423193 abstract "Several studies suggest that brain-derived neurotrophic factor (BDNF) can exacerbate seizure development during status epilepticus (S.E.) and subsequent epileptogenesis in the adult brain. On the other hand, evidence exists for the protective effect of BDNF. To study this controversy, we induced S.E. with kainate in transgenic mice with increased BDNF signaling due to trkB overexpression. Transgenic mice experienced a more severe S.E. than wild type animals did. Furthermore, they had increased acute hippocampal neuronal loss when assessed at 48 h after S.E. The effect of trkB overexpression on the development of epilepsy, chronic neuronal death, mossy fiber sprouting, and neurogenesis were studied at 4.5 months after kainate-induced S.E. No differences were found in the rate of epileptogenesis, severity of epilepsy, or cellular markers of network reorganization between transgenic and wild type mice. No differences between genotypes were observed in TUC-4 staining, indicating no effect of trkB overexpression to immature neuron numbers. Instead, in Cresyl Violet-stained preparations, the highest density of neurons was found in untreated transgenic mice suggesting a favorable effect of trkB overexpression on the survival of neurons in the hippocampus. Our data support the role of BDNF and trkB signaling in seizure generation and acute cellular damage after S.E. Long-term outcome was not, however, exacerbated by trkB overexpression." @default.
- W2027423193 created "2016-06-24" @default.
- W2027423193 creator A5001493420 @default.
- W2027423193 creator A5012489670 @default.
- W2027423193 creator A5019744869 @default.
- W2027423193 creator A5021316122 @default.
- W2027423193 creator A5091914497 @default.
- W2027423193 date "2003-01-01" @default.
- W2027423193 modified "2023-10-09" @default.
- W2027423193 title "Exacerbated status epilepticus and acute cell loss, but no changes in epileptogenesis, in mice with increased brain-derived neurotrophic factor signaling" @default.
- W2027423193 cites W1508232918 @default.
- W2027423193 cites W1533790491 @default.
- W2027423193 cites W1548974019 @default.
- W2027423193 cites W1574757902 @default.
- W2027423193 cites W1747922801 @default.
- W2027423193 cites W1827373965 @default.
- W2027423193 cites W1942924653 @default.
- W2027423193 cites W1969408505 @default.
- W2027423193 cites W1970846544 @default.
- W2027423193 cites W1971188677 @default.
- W2027423193 cites W1980584574 @default.
- W2027423193 cites W1984253712 @default.
- W2027423193 cites W1986844251 @default.
- W2027423193 cites W1987313743 @default.
- W2027423193 cites W1987407476 @default.
- W2027423193 cites W1987904402 @default.
- W2027423193 cites W1991251782 @default.
- W2027423193 cites W1996785105 @default.
- W2027423193 cites W2002073425 @default.
- W2027423193 cites W2002940293 @default.
- W2027423193 cites W2012825989 @default.
- W2027423193 cites W2013137971 @default.
- W2027423193 cites W2013235905 @default.
- W2027423193 cites W2015047283 @default.
- W2027423193 cites W2031428136 @default.
- W2027423193 cites W2033333756 @default.
- W2027423193 cites W2035562497 @default.
- W2027423193 cites W2038278300 @default.
- W2027423193 cites W2038465691 @default.
- W2027423193 cites W2039736236 @default.
- W2027423193 cites W2044842078 @default.
- W2027423193 cites W2044857503 @default.
- W2027423193 cites W2049521887 @default.
- W2027423193 cites W2055189490 @default.
- W2027423193 cites W2058479911 @default.
- W2027423193 cites W2058887458 @default.
- W2027423193 cites W2060653979 @default.
- W2027423193 cites W2070932424 @default.
- W2027423193 cites W2076843536 @default.
- W2027423193 cites W2085298903 @default.
- W2027423193 cites W2086835104 @default.
- W2027423193 cites W2088285277 @default.
- W2027423193 cites W2092700031 @default.
- W2027423193 cites W2093320992 @default.
- W2027423193 cites W2103350456 @default.
- W2027423193 cites W2103946141 @default.
- W2027423193 cites W2124486647 @default.
- W2027423193 cites W2138152051 @default.
- W2027423193 cites W2139289922 @default.
- W2027423193 cites W2150936467 @default.
- W2027423193 cites W2151260972 @default.
- W2027423193 cites W2154409965 @default.
- W2027423193 cites W2163639252 @default.
- W2027423193 cites W2164730488 @default.
- W2027423193 cites W2165064374 @default.
- W2027423193 cites W2339433485 @default.
- W2027423193 cites W4206810002 @default.
- W2027423193 cites W4241352627 @default.
- W2027423193 doi "https://doi.org/10.1016/j.neuroscience.2003.08.037" @default.
- W2027423193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14643774" @default.
- W2027423193 hasPublicationYear "2003" @default.
- W2027423193 type Work @default.
- W2027423193 sameAs 2027423193 @default.
- W2027423193 citedByCount "58" @default.
- W2027423193 countsByYear W20274231932012 @default.
- W2027423193 countsByYear W20274231932013 @default.
- W2027423193 countsByYear W20274231932014 @default.
- W2027423193 countsByYear W20274231932015 @default.
- W2027423193 countsByYear W20274231932016 @default.
- W2027423193 countsByYear W20274231932017 @default.
- W2027423193 countsByYear W20274231932018 @default.
- W2027423193 countsByYear W20274231932019 @default.
- W2027423193 countsByYear W20274231932021 @default.
- W2027423193 countsByYear W20274231932022 @default.
- W2027423193 crossrefType "journal-article" @default.
- W2027423193 hasAuthorship W2027423193A5001493420 @default.
- W2027423193 hasAuthorship W2027423193A5012489670 @default.
- W2027423193 hasAuthorship W2027423193A5019744869 @default.
- W2027423193 hasAuthorship W2027423193A5021316122 @default.
- W2027423193 hasAuthorship W2027423193A5091914497 @default.
- W2027423193 hasConcept C126322002 @default.
- W2027423193 hasConcept C134018914 @default.
- W2027423193 hasConcept C148762608 @default.
- W2027423193 hasConcept C160268369 @default.
- W2027423193 hasConcept C160539049 @default.
- W2027423193 hasConcept C169760540 @default.
- W2027423193 hasConcept C170493617 @default.
- W2027423193 hasConcept C189184402 @default.