FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027423466> ?p ?o ?g. }

• W2027423466 endingPage "254" @default.
• W2027423466 startingPage "246" @default.
• W2027423466 abstract "An 8-month-old, spayed female Shetland sheepdog presented 48 hours after ingesting acetaminophen (1 gm/kg body weight). On presentation, the dog was laterally recumbent and hypovolemic. The dog had brown mucous membranes, severe Heinz-body hemolytic anemia, bleeding tendencies, and a red blood cell (RBC) glutathione (GSH) concentration that was 10% of reference values, despite a regenerative erythroid response. Treatment with s-adenosyl-l-methionine (SAMe) as a GSH donor successfully rescued this dog, despite the animal’s late presentation after drug ingestion. A loading dose (40 mg/kg body weight) of a stable SAMe salt per os was followed by a maintenance dose (20 mg/kg body weight) sid for 7 days. Additional therapeutic interventions included an intravenous (IV) infusion of one unit of packed RBCs (on admission), IV fluid support (3 days), and famotidine (7 days) to reduce gastric acidity. Sequential assessment of RBC GSH concentrations and RBC morphology documented response to antidote administration within 72 hours. This case suggests that SAMe may provide a therapeutic option for treatment of acetaminophen toxicosis in dogs capable of retaining an orally administered antidote and maintaining adequate hepatic function for metabolism of SAMe to its thiol substrates." @default.
• W2027423466 created "2016-06-24" @default.
• W2027423466 creator A5043294209 @default.
• W2027423466 creator A5054492924 @default.
• W2027423466 creator A5057531273 @default.
• W2027423466 creator A5070886278 @default.
• W2027423466 creator A5075879804 @default.
• W2027423466 date "2002-05-01" @default.
• W2027423466 modified "2023-10-16" @default.
• W2027423466 title "S-Adenosyl-L-Methionine (SAMe) for the Treatment of Acetaminophen Toxicity in a Dog" @default.
• W2027423466 cites W1604994584 @default.
• W2027423466 cites W1662066112 @default.
• W2027423466 cites W1826866815 @default.
• W2027423466 cites W1964961878 @default.
• W2027423466 cites W1972269499 @default.
• W2027423466 cites W1977925746 @default.
• W2027423466 cites W1986605633 @default.
• W2027423466 cites W2008046766 @default.
• W2027423466 cites W2029442764 @default.
• W2027423466 cites W2033024401 @default.
• W2027423466 cites W2050620959 @default.
• W2027423466 cites W2054534199 @default.
• W2027423466 cites W2059096914 @default.
• W2027423466 cites W2064435261 @default.
• W2027423466 cites W2070159364 @default.
• W2027423466 cites W2074291228 @default.
• W2027423466 cites W2078129861 @default.
• W2027423466 cites W2082669244 @default.
• W2027423466 cites W2087171263 @default.
• W2027423466 cites W2088964888 @default.
• W2027423466 cites W2094122101 @default.
• W2027423466 cites W2094762710 @default.
• W2027423466 cites W2114977162 @default.
• W2027423466 cites W2123132907 @default.
• W2027423466 cites W2140507133 @default.
• W2027423466 cites W2258939519 @default.
• W2027423466 cites W2333107025 @default.
• W2027423466 cites W2417144739 @default.
• W2027423466 cites W2518970748 @default.
• W2027423466 cites W2766731651 @default.
• W2027423466 cites W4235509352 @default.
• W2027423466 cites W83660317 @default.
• W2027423466 cites W2014676335 @default.
• W2027423466 doi "https://doi.org/10.5326/0380246" @default.
• W2027423466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12022411" @default.
• W2027423466 hasPublicationYear "2002" @default.
• W2027423466 type Work @default.
• W2027423466 sameAs 2027423466 @default.
• W2027423466 citedByCount "61" @default.
• W2027423466 countsByYear W20274234662012 @default.
• W2027423466 countsByYear W20274234662013 @default.
• W2027423466 countsByYear W20274234662014 @default.
• W2027423466 countsByYear W20274234662015 @default.
• W2027423466 countsByYear W20274234662016 @default.
• W2027423466 countsByYear W20274234662017 @default.
• W2027423466 countsByYear W20274234662018 @default.
• W2027423466 countsByYear W20274234662019 @default.
• W2027423466 countsByYear W20274234662020 @default.
• W2027423466 countsByYear W20274234662023 @default.
• W2027423466 crossrefType "journal-article" @default.
• W2027423466 hasAuthorship W2027423466A5043294209 @default.
• W2027423466 hasAuthorship W2027423466A5054492924 @default.
• W2027423466 hasAuthorship W2027423466A5057531273 @default.
• W2027423466 hasAuthorship W2027423466A5070886278 @default.
• W2027423466 hasAuthorship W2027423466A5075879804 @default.
• W2027423466 hasConcept C126322002 @default.
• W2027423466 hasConcept C151666851 @default.
• W2027423466 hasConcept C181199279 @default.
• W2027423466 hasConcept C185592680 @default.
• W2027423466 hasConcept C193230392 @default.
• W2027423466 hasConcept C2778248108 @default.
• W2027423466 hasConcept C2778722691 @default.
• W2027423466 hasConcept C2778917026 @default.
• W2027423466 hasConcept C2779365888 @default.
• W2027423466 hasConcept C29730261 @default.
• W2027423466 hasConcept C42219234 @default.
• W2027423466 hasConcept C42407357 @default.
• W2027423466 hasConcept C538909803 @default.
• W2027423466 hasConcept C55493867 @default.
• W2027423466 hasConcept C71924100 @default.
• W2027423466 hasConcept C98274493 @default.
• W2027423466 hasConceptScore W2027423466C126322002 @default.
• W2027423466 hasConceptScore W2027423466C151666851 @default.
• W2027423466 hasConceptScore W2027423466C181199279 @default.
• W2027423466 hasConceptScore W2027423466C185592680 @default.
• W2027423466 hasConceptScore W2027423466C193230392 @default.
• W2027423466 hasConceptScore W2027423466C2778248108 @default.
• W2027423466 hasConceptScore W2027423466C2778722691 @default.
• W2027423466 hasConceptScore W2027423466C2778917026 @default.
• W2027423466 hasConceptScore W2027423466C2779365888 @default.
• W2027423466 hasConceptScore W2027423466C29730261 @default.
• W2027423466 hasConceptScore W2027423466C42219234 @default.
• W2027423466 hasConceptScore W2027423466C42407357 @default.
• W2027423466 hasConceptScore W2027423466C538909803 @default.
• W2027423466 hasConceptScore W2027423466C55493867 @default.
• W2027423466 hasConceptScore W2027423466C71924100 @default.
• W2027423466 hasConceptScore W2027423466C98274493 @default.
• W2027423466 hasIssue "3" @default.

• next