Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027424128> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2027424128 endingPage "640" @default.
- W2027424128 startingPage "633" @default.
- W2027424128 abstract "Thioureas are oxygenated by flavin-containing monooxygenases (FMOs), forming reactive sulfenic and/or sulfinic acids. Sulfenic acids can reversibly react with GSH and drive oxidative stress through a redox cycle. For this reason, thiourea S-oxygenation is an example of FMO-dependent bioactivation of a xenobiotic. Functional FMO2 is expressed in the lung of 26% of individuals of African descent and 5% of Hispanics but not in Caucasians or Asians. We have previously demonstrated that human FMO2.1 protein expressed in Sf9 microsomes has high activity toward a series of thioureas that are known or suspected lung toxicants including thiourea, 1-phenylthiourea, and ethylenethiourea. We now show by HPLC and LC-MS that 1-phenylthiourea and alpha-naphthylthiourea are converted to their sulfenic acids. GSH in the incubations at concentrations of 0.5-1.0 mM completely eliminated the sulfenic acid with resultant production of GSSG. These results indicate that individuals with the FMO21 allele may be at enhanced risk of pulmonary damage upon exposure to thioureas." @default.
- W2027424128 created "2016-06-24" @default.
- W2027424128 creator A5012008989 @default.
- W2027424128 creator A5016370606 @default.
- W2027424128 creator A5074541832 @default.
- W2027424128 creator A5086708085 @default.
- W2027424128 date "2004-04-13" @default.
- W2027424128 modified "2023-10-16" @default.
- W2027424128 title "Human Flavin-Containing Monooxygenase Form 2 S-Oxygenation: Sulfenic Acid Formation from Thioureas and Oxidation of Glutathione" @default.
- W2027424128 cites W1528054778 @default.
- W2027424128 cites W2045798325 @default.
- W2027424128 cites W2100536490 @default.
- W2027424128 cites W2102994840 @default.
- W2027424128 cites W2163124624 @default.
- W2027424128 cites W4243048085 @default.
- W2027424128 doi "https://doi.org/10.1021/tx034253s" @default.
- W2027424128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15144220" @default.
- W2027424128 hasPublicationYear "2004" @default.
- W2027424128 type Work @default.
- W2027424128 sameAs 2027424128 @default.
- W2027424128 citedByCount "73" @default.
- W2027424128 countsByYear W20274241282012 @default.
- W2027424128 countsByYear W20274241282013 @default.
- W2027424128 countsByYear W20274241282014 @default.
- W2027424128 countsByYear W20274241282015 @default.
- W2027424128 countsByYear W20274241282016 @default.
- W2027424128 countsByYear W20274241282017 @default.
- W2027424128 countsByYear W20274241282018 @default.
- W2027424128 countsByYear W20274241282019 @default.
- W2027424128 countsByYear W20274241282020 @default.
- W2027424128 countsByYear W20274241282022 @default.
- W2027424128 crossrefType "journal-article" @default.
- W2027424128 hasAuthorship W2027424128A5012008989 @default.
- W2027424128 hasAuthorship W2027424128A5016370606 @default.
- W2027424128 hasAuthorship W2027424128A5074541832 @default.
- W2027424128 hasAuthorship W2027424128A5086708085 @default.
- W2027424128 hasConcept C13002179 @default.
- W2027424128 hasConcept C178790620 @default.
- W2027424128 hasConcept C181199279 @default.
- W2027424128 hasConcept C185592680 @default.
- W2027424128 hasConcept C2776146729 @default.
- W2027424128 hasConcept C2779201268 @default.
- W2027424128 hasConcept C2780158455 @default.
- W2027424128 hasConcept C2780538656 @default.
- W2027424128 hasConcept C2781324293 @default.
- W2027424128 hasConcept C33093398 @default.
- W2027424128 hasConcept C526171541 @default.
- W2027424128 hasConcept C538909803 @default.
- W2027424128 hasConcept C55493867 @default.
- W2027424128 hasConcept C71240020 @default.
- W2027424128 hasConceptScore W2027424128C13002179 @default.
- W2027424128 hasConceptScore W2027424128C178790620 @default.
- W2027424128 hasConceptScore W2027424128C181199279 @default.
- W2027424128 hasConceptScore W2027424128C185592680 @default.
- W2027424128 hasConceptScore W2027424128C2776146729 @default.
- W2027424128 hasConceptScore W2027424128C2779201268 @default.
- W2027424128 hasConceptScore W2027424128C2780158455 @default.
- W2027424128 hasConceptScore W2027424128C2780538656 @default.
- W2027424128 hasConceptScore W2027424128C2781324293 @default.
- W2027424128 hasConceptScore W2027424128C33093398 @default.
- W2027424128 hasConceptScore W2027424128C526171541 @default.
- W2027424128 hasConceptScore W2027424128C538909803 @default.
- W2027424128 hasConceptScore W2027424128C55493867 @default.
- W2027424128 hasConceptScore W2027424128C71240020 @default.
- W2027424128 hasIssue "5" @default.
- W2027424128 hasLocation W20274241281 @default.
- W2027424128 hasLocation W20274241282 @default.
- W2027424128 hasOpenAccess W2027424128 @default.
- W2027424128 hasPrimaryLocation W20274241281 @default.
- W2027424128 hasRelatedWork W1963698574 @default.
- W2027424128 hasRelatedWork W1992439512 @default.
- W2027424128 hasRelatedWork W2005846619 @default.
- W2027424128 hasRelatedWork W2027424128 @default.
- W2027424128 hasRelatedWork W2042561904 @default.
- W2027424128 hasRelatedWork W2051549153 @default.
- W2027424128 hasRelatedWork W2096063757 @default.
- W2027424128 hasRelatedWork W2529030140 @default.
- W2027424128 hasRelatedWork W3017325546 @default.
- W2027424128 hasRelatedWork W4362671562 @default.
- W2027424128 hasVolume "17" @default.
- W2027424128 isParatext "false" @default.
- W2027424128 isRetracted "false" @default.
- W2027424128 magId "2027424128" @default.
- W2027424128 workType "article" @default.