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- W2027424984 abstract "Over the last years, antimicrobial peptides (AMPs) have been the focus of intense research towards the finding of a viable alternative to current antifungal drugs. Defensins are one of the major families of AMPs and the most represented among all eukaryotic groups, providing an important first line of host defense against pathogenic microorganisms. Several of these cysteine-stabilized peptides present a relevant effect against fungi. Defensins are the AMPs with the broader distribution across all eukaryotic kingdoms, namely, Fungi, Plantæ and Animalia, and were recently shown to have an ancestor in a bacterial organism. As a part of the host defense, defensins act as an important vehicle of information between innate and adaptive immune system and have a role in immunomodulation. This multidimensionality represents a powerful host shield, hard for microorganisms to overcome using single approach resistance strategies. Pathogenic fungi resistance to conventional antimycotic drugs is becoming a major problem. Defensins, as other AMPs, have shown to be an effective alternative to the current antimycotic therapies, demonstrating potential as novel therapeutic agents or drug leads. In this review, we summarize the current knowledge on some eukaryotic defensins with antifungal action. An overview of the main targets in the fungal cell and the mechanism of action of these AMPs (namely, the selectivity for some fungal membrane components) are presented. Additionally, recent works on antifungal defensins structure, activity and citotoxicity are also reviewed." @default.
- W2027424984 created "2016-06-24" @default.
- W2027424984 creator A5003344210 @default.
- W2027424984 creator A5035897086 @default.
- W2027424984 creator A5060192358 @default.
- W2027424984 date "2014-03-20" @default.
- W2027424984 modified "2023-09-27" @default.
- W2027424984 title "Defensins: antifungal lessons from eukaryotes" @default.
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