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• W2027427419 abstract "Abstract To better understand the tissue iron overload and anemia previously reported in a human patient and mice that lack heme oxygenase-1 (HO-1), we studied iron distribution and pathology in HO-1(Hmox1)−/− mice. We found that resident splenic and liver macrophages were mostly absent in HO-1−/− mice. Erythrophagocytosis caused the death of HO-1−/− macrophages in in vitro experiments, supporting the hypothesis that HO-1−/− macrophages died of exposure to heme released on erythrophagocytosis. Rupture of HO-1−/− macrophages in vivo and release of nonmetabolized heme probably caused tissue inflammation. In the spleen, initial splenic enlargement progressed to red pulp fibrosis, atrophy, and functional hyposplenism in older mice, recapitulating the asplenia of an HO-1–deficient patient. We postulate that the failure of tissue macrophages to remove senescent erythrocytes led to intravascular hemolysis and increased expression of the heme and hemoglobin scavenger proteins, hemopexin and haptoglobin. Lack of macrophages expressing the haptoglobin receptor, CD163, diminished the ability of haptoglobin to neutralize circulating hemoglobin, and iron overload occurred in kidney proximal tubules, which were able to catabolize heme with HO-2. Thus, in HO-1−/− mammals, the reduced function and viability of erythrophagocytosing macrophages are the main causes of tissue damage and iron redistribution." @default.
• W2027427419 created "2016-06-24" @default.
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• W2027427419 date "2010-12-23" @default.
• W2027427419 modified "2023-10-16" @default.
• W2027427419 title "Dysfunction of the heme recycling system in heme oxygenase 1–deficient mice: effects on macrophage viability and tissue iron distribution" @default.
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• W2027427419 doi "https://doi.org/10.1182/blood-2010-03-272138" @default.
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