Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027428229> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2027428229 endingPage "249" @default.
- W2027428229 startingPage "244" @default.
- W2027428229 abstract "In our recent studies, we defined a critical role for increased levels of myosin light chain (MLC) phosphorylation, a regulatory event in the interaction between actin and myosin in TNF-alpha-induced pulmonary endothelial cell actomyosin rearrangement and apoptosis. The Rho GTPase effector, Rho kinase is an important signaling effector governing levels of MLC phosphorylation which contributes to plasma membrane blebbing in several models of apoptosis. In this study, we directly assessed the role of Rho kinase in TNF-alpha-induced endothelial cell microfilament rearrangement and apoptosis. Inhibition of RhoA GTPase activity by the overexpression of dominant negative RhoA attenuates TNF-alpha-triggered stress fiber formation, consistent with Rho activation as a key event in TNF-alpha-induced cytoskeletal rearrangement. Furthermore, pharmacologic inhibition of Rho kinase as well as dominant negative RhoA overexpression dramatically reduced TNF-alpha-induced bovine endothelial apoptosis reflected by nucleosomal fragmentation as well as caspase 7, 3, and 8 activation. These results indicate that Rho kinase-dependent cytoskeletal rearrangement is critical for early apoptotic events, possibly in the assembly of the death-inducing signaling complex leading to initiator and effector caspase activation, and suggest a novel role for Rho GTPases in endothelial cell apoptosis." @default.
- W2027428229 created "2016-06-24" @default.
- W2027428229 creator A5022918301 @default.
- W2027428229 creator A5026411789 @default.
- W2027428229 creator A5052491243 @default.
- W2027428229 creator A5087842818 @default.
- W2027428229 date "2003-06-01" @default.
- W2027428229 modified "2023-10-14" @default.
- W2027428229 title "Central involvement of Rho family GTPases in TNF-α-mediated bovine pulmonary endothelial cell apoptosis" @default.
- W2027428229 cites W1836073275 @default.
- W2027428229 cites W1967912613 @default.
- W2027428229 cites W1971996726 @default.
- W2027428229 cites W1983640053 @default.
- W2027428229 cites W1985411011 @default.
- W2027428229 cites W1997087774 @default.
- W2027428229 cites W2032295238 @default.
- W2027428229 cites W2042087846 @default.
- W2027428229 cites W2044506661 @default.
- W2027428229 cites W2048548596 @default.
- W2027428229 cites W2057163366 @default.
- W2027428229 cites W2081245863 @default.
- W2027428229 cites W2087921363 @default.
- W2027428229 cites W2112634792 @default.
- W2027428229 cites W2116007831 @default.
- W2027428229 cites W2133408841 @default.
- W2027428229 cites W2160062367 @default.
- W2027428229 doi "https://doi.org/10.1016/s0006-291x(03)00945-8" @default.
- W2027428229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12788095" @default.
- W2027428229 hasPublicationYear "2003" @default.
- W2027428229 type Work @default.
- W2027428229 sameAs 2027428229 @default.
- W2027428229 citedByCount "62" @default.
- W2027428229 countsByYear W20274282292012 @default.
- W2027428229 countsByYear W20274282292013 @default.
- W2027428229 countsByYear W20274282292014 @default.
- W2027428229 countsByYear W20274282292015 @default.
- W2027428229 countsByYear W20274282292016 @default.
- W2027428229 countsByYear W20274282292017 @default.
- W2027428229 countsByYear W20274282292019 @default.
- W2027428229 countsByYear W20274282292020 @default.
- W2027428229 countsByYear W20274282292021 @default.
- W2027428229 countsByYear W20274282292022 @default.
- W2027428229 countsByYear W20274282292023 @default.
- W2027428229 crossrefType "journal-article" @default.
- W2027428229 hasAuthorship W2027428229A5022918301 @default.
- W2027428229 hasAuthorship W2027428229A5026411789 @default.
- W2027428229 hasAuthorship W2027428229A5052491243 @default.
- W2027428229 hasAuthorship W2027428229A5087842818 @default.
- W2027428229 hasConcept C11960822 @default.
- W2027428229 hasConcept C142669718 @default.
- W2027428229 hasConcept C1491633281 @default.
- W2027428229 hasConcept C151166631 @default.
- W2027428229 hasConcept C190283241 @default.
- W2027428229 hasConcept C201800478 @default.
- W2027428229 hasConcept C207332259 @default.
- W2027428229 hasConcept C2777093181 @default.
- W2027428229 hasConcept C2781099445 @default.
- W2027428229 hasConcept C55493867 @default.
- W2027428229 hasConcept C62478195 @default.
- W2027428229 hasConcept C8035138 @default.
- W2027428229 hasConcept C86803240 @default.
- W2027428229 hasConcept C95444343 @default.
- W2027428229 hasConceptScore W2027428229C11960822 @default.
- W2027428229 hasConceptScore W2027428229C142669718 @default.
- W2027428229 hasConceptScore W2027428229C1491633281 @default.
- W2027428229 hasConceptScore W2027428229C151166631 @default.
- W2027428229 hasConceptScore W2027428229C190283241 @default.
- W2027428229 hasConceptScore W2027428229C201800478 @default.
- W2027428229 hasConceptScore W2027428229C207332259 @default.
- W2027428229 hasConceptScore W2027428229C2777093181 @default.
- W2027428229 hasConceptScore W2027428229C2781099445 @default.
- W2027428229 hasConceptScore W2027428229C55493867 @default.
- W2027428229 hasConceptScore W2027428229C62478195 @default.
- W2027428229 hasConceptScore W2027428229C8035138 @default.
- W2027428229 hasConceptScore W2027428229C86803240 @default.
- W2027428229 hasConceptScore W2027428229C95444343 @default.
- W2027428229 hasIssue "1" @default.
- W2027428229 hasLocation W20274282291 @default.
- W2027428229 hasLocation W20274282292 @default.
- W2027428229 hasOpenAccess W2027428229 @default.
- W2027428229 hasPrimaryLocation W20274282291 @default.
- W2027428229 hasRelatedWork W1556045283 @default.
- W2027428229 hasRelatedWork W1750949018 @default.
- W2027428229 hasRelatedWork W1986799194 @default.
- W2027428229 hasRelatedWork W2024546609 @default.
- W2027428229 hasRelatedWork W2051351245 @default.
- W2027428229 hasRelatedWork W2058020276 @default.
- W2027428229 hasRelatedWork W2062199496 @default.
- W2027428229 hasRelatedWork W2078355306 @default.
- W2027428229 hasRelatedWork W2083762494 @default.
- W2027428229 hasRelatedWork W2105571324 @default.
- W2027428229 hasVolume "306" @default.
- W2027428229 isParatext "false" @default.
- W2027428229 isRetracted "false" @default.
- W2027428229 magId "2027428229" @default.
- W2027428229 workType "article" @default.