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- W2027428693 abstract "Background: Anemia is recognized as a potentially important pathophysiological factor in heart failure (HF), possibly by reducing oxygen delivery and likely other mechanisms. However, little is known about the prevalence of anemia or clinical factors associated with the occurrence of anemia in unselected patients with HF. Available data are primarily derived from retrospective analyses of prospectively collected data from selected HF populations. The primary objectives of the STAMINA-HFP registry are to estimate the prevalence and incidence of anemia and identify factors associated with anemia in a broad population of outpatients with HF. Methods: The STAMINA-HFP Registry is currently ongoing and utilizes a prospective, observational design. 1000 outpatients will be randomly selected from HF specialty clinics involved in the UNITE-HF database (n = 400) and community cardiology practice clinics (n = 600). Inclusion criteria are broad. HF was clinically diagnosed based on the occurrence of fluid retention and/or dyspnea due to cardiac cause regardless of left ventricular ejection fraction. Baseline assessment includes a comprehensive clinical history, CBC and serum creatinine. Follow-up in the outpatient clinic is naturalistic for one year with serial hemoglobin measurements obtained by finger stick at clinically indicated visits. Patient reported outcomes (PRO) will be assessed by telephone contact at baseline and every three months for one year using the Kansas City Cardiomyopathy Questionnaire, Minnesota Living with Heart Failure Questionnaire, and the FACIT-Fatigue instrument. Data on death and hospitalization will be collected and these outcomes evaluated using an event committee. Results: To date, 942 subjects have been enrolled at 56 sites. Baseline data from 625 subjects (173 specialty and 452 community) revealed that the cohort is 43% female and 75% Caucasian with mean (±SD) age of 64±14 years (57±15 years in specialty and 68±13 years in community sites, p<0.001). 24% of subjects had a hemoglobin level<12 g/dL; a history of diabetes was present in 39% and hypertension in 72% of subjects. Conclusion: The STAMINA-HFP Registry will provide contemporary data on the prevalence of anemia in outpatients with HF seen in specialty and community cardiology clinics. The registry will identify factors associated with anemia and evaluate the relationship between anemia and PRO in a broad population of subjects with HF." @default.
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- W2027428693 date "2003-10-01" @default.
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- W2027428693 title "STAMINA-HFP (study of anemia in a heart failure population) registry: rationale, design, and patient characteristics" @default.
- W2027428693 doi "https://doi.org/10.1016/s1071-9164(03)00252-5" @default.
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