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- W2027429495 abstract "A series of substituted sulphonamides has been prepared for a study of their chemotherapeutic activity against a number of different bacterial species. By condensing p-acetylaminobenzenesulphonyl chloride with primary aromatic and aliphatic amines, N 4 -acetyl-N 1 –substituted sulphanilamides were obtained. Hydrolysis with acid or alkali removed the acetyl group and gave the desired N 1 -substituted sulphanilamides.The appendix contains details of the techniques used in testing these sulphonamides. Although a few of the compounds described in this paper exhibit considerable in vitro activity, none of them possess, in vivo, chemotherapeutic properties equal to those of sulfapyridine or sulfathiazole." @default.
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- W2027429495 date "1942-01-01" @default.
- W2027429495 modified "2023-10-17" @default.
- W2027429495 title "CHEMOTHERAPEUTIC STUDIES: PREPARATION OF SUBSTITUTED SULPHONAMIDES" @default.
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- W2027429495 doi "https://doi.org/10.1139/cjr42b-002" @default.
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