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- W2027431046 abstract "Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity against HSV-1 and HSV-2 in Vero cell antiviral assays. Here, we describe the synthesis and anti-herpetic activity of several 3-pyrimidinyl-2-phenylpyrazolo[1,5-a]pyridines with differing 2-phenyl substitution patterns. Approaches to rapidly access a number of analogs with different 2-phenyl substitution patterns are outlined. Several of the compounds described have comparable activity to acyclovir against HSV-1 and HSV-2." @default.
- W2027431046 created "2016-06-24" @default.
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- W2027431046 date "2005-09-01" @default.
- W2027431046 modified "2023-10-17" @default.
- W2027431046 title "Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses" @default.
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- W2027431046 doi "https://doi.org/10.1016/j.bmc.2005.05.043" @default.
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