Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027442034> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2027442034 endingPage "438" @default.
- W2027442034 startingPage "431" @default.
- W2027442034 abstract "Liu-Shen-Wan (LSW), an ancient preparation used to treat localized infection with pain, was recently reported to possess anticancer activity. The mechanism responsible for LSW’s analgesic and anticancer activity is unclear. In the present study, we obtained a LSW supernatant (LSWS) fraction from ultrasound-assisted ethanol extraction (yield 15.9%) which proved to be safer than LSW in terms of hepatotoxicity. The LSWS (1 and 10 µg/mL) exhibited a potent inhibitory effect on the bradykinin-evoked rapid release of substance P from dorsal root ganglion (DRG) cells. At concentrations of 0.1 µg/mL and higher, the LSWS resulted in a concentration-related growth inhibitory effect on HepG2, a representative cancer cell lines. The LSWS significantly down-regulated the neurokinin-1 (NK-1) receptor expression in both HepG2 and bradykinin-treated DRG cells. In addition to the NK-1 receptor-dependent growth inhibition in HepG2 cells (0.1–100 µg/mL), the LSWS induced mitochondria-mediated apoptosis at a higher concentration (1–100 µg/mL). In conclusion, we recently isolated a safer LSW fraction which maintained its analgesic and anticancer activity, and found that the substance P/NK-1 receptor system was partly responsible for these effects. Our findings will be useful for developing more effective and less toxic LSW preparations." @default.
- W2027442034 created "2016-06-24" @default.
- W2027442034 creator A5012094328 @default.
- W2027442034 creator A5012186139 @default.
- W2027442034 creator A5023726058 @default.
- W2027442034 creator A5046543918 @default.
- W2027442034 creator A5059417727 @default.
- W2027442034 creator A5074011852 @default.
- W2027442034 date "2014-01-01" @default.
- W2027442034 modified "2023-10-02" @default.
- W2027442034 title "Involvement of Substance P/Neurokinin-1 Receptor in the Analgesic and Anticancer Activities of Minimally Toxic Fraction from the Traditional Chinese Medicine Liu-Shen-Wan <i>in Vitro</i>" @default.
- W2027442034 cites W2005119541 @default.
- W2027442034 cites W2010096250 @default.
- W2027442034 cites W2010286023 @default.
- W2027442034 cites W2017692306 @default.
- W2027442034 cites W2086488050 @default.
- W2027442034 cites W2414763135 @default.
- W2027442034 doi "https://doi.org/10.1248/bpb.b13-00794" @default.
- W2027442034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24366059" @default.
- W2027442034 hasPublicationYear "2014" @default.
- W2027442034 type Work @default.
- W2027442034 sameAs 2027442034 @default.
- W2027442034 citedByCount "10" @default.
- W2027442034 countsByYear W20274420342015 @default.
- W2027442034 countsByYear W20274420342016 @default.
- W2027442034 countsByYear W20274420342018 @default.
- W2027442034 countsByYear W20274420342020 @default.
- W2027442034 countsByYear W20274420342021 @default.
- W2027442034 countsByYear W20274420342023 @default.
- W2027442034 crossrefType "journal-article" @default.
- W2027442034 hasAuthorship W2027442034A5012094328 @default.
- W2027442034 hasAuthorship W2027442034A5012186139 @default.
- W2027442034 hasAuthorship W2027442034A5023726058 @default.
- W2027442034 hasAuthorship W2027442034A5046543918 @default.
- W2027442034 hasAuthorship W2027442034A5059417727 @default.
- W2027442034 hasAuthorship W2027442034A5074011852 @default.
- W2027442034 hasBestOaLocation W20274420341 @default.
- W2027442034 hasConcept C118303440 @default.
- W2027442034 hasConcept C137130169 @default.
- W2027442034 hasConcept C170493617 @default.
- W2027442034 hasConcept C185592680 @default.
- W2027442034 hasConcept C190283241 @default.
- W2027442034 hasConcept C202751555 @default.
- W2027442034 hasConcept C2776533618 @default.
- W2027442034 hasConcept C2777389121 @default.
- W2027442034 hasConcept C2779591629 @default.
- W2027442034 hasConcept C2780820201 @default.
- W2027442034 hasConcept C2781063702 @default.
- W2027442034 hasConcept C55493867 @default.
- W2027442034 hasConcept C71924100 @default.
- W2027442034 hasConcept C98274493 @default.
- W2027442034 hasConceptScore W2027442034C118303440 @default.
- W2027442034 hasConceptScore W2027442034C137130169 @default.
- W2027442034 hasConceptScore W2027442034C170493617 @default.
- W2027442034 hasConceptScore W2027442034C185592680 @default.
- W2027442034 hasConceptScore W2027442034C190283241 @default.
- W2027442034 hasConceptScore W2027442034C202751555 @default.
- W2027442034 hasConceptScore W2027442034C2776533618 @default.
- W2027442034 hasConceptScore W2027442034C2777389121 @default.
- W2027442034 hasConceptScore W2027442034C2779591629 @default.
- W2027442034 hasConceptScore W2027442034C2780820201 @default.
- W2027442034 hasConceptScore W2027442034C2781063702 @default.
- W2027442034 hasConceptScore W2027442034C55493867 @default.
- W2027442034 hasConceptScore W2027442034C71924100 @default.
- W2027442034 hasConceptScore W2027442034C98274493 @default.
- W2027442034 hasIssue "3" @default.
- W2027442034 hasLocation W20274420341 @default.
- W2027442034 hasLocation W20274420342 @default.
- W2027442034 hasOpenAccess W2027442034 @default.
- W2027442034 hasPrimaryLocation W20274420341 @default.
- W2027442034 hasRelatedWork W1943889744 @default.
- W2027442034 hasRelatedWork W1991937804 @default.
- W2027442034 hasRelatedWork W2006621537 @default.
- W2027442034 hasRelatedWork W2027442034 @default.
- W2027442034 hasRelatedWork W2111569334 @default.
- W2027442034 hasRelatedWork W2165671231 @default.
- W2027442034 hasRelatedWork W2408872284 @default.
- W2027442034 hasRelatedWork W4206871862 @default.
- W2027442034 hasRelatedWork W4287435042 @default.
- W2027442034 hasRelatedWork W4318830844 @default.
- W2027442034 hasVolume "37" @default.
- W2027442034 isParatext "false" @default.
- W2027442034 isRetracted "false" @default.
- W2027442034 magId "2027442034" @default.
- W2027442034 workType "article" @default.