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• W2027454940 abstract "Since the discovery of the immunoglobulin (Ig) µ intronic enhancer 16 years ago (Banerji et al. 1983; Gilleset al. 1983), the B- and T-lymphocyte differentiationpathways have served as important models for analyzingthe cell- and developmental stage-specific regulation oftranscription by mammalian RNA polymerase II. Fromstudies of several lymphocyte-specific genes, includingthe Ig µ, Ig κ, T cell receptor α, and CD4 genes, fundamental principles of mammalian transcriptional regulation have emerged. First, the precise expression pattern ofa mammalian gene depends on information supplied bythe promoter region, located in the vicinity of the transcription start site, and also by distant control regions(i.e., enhancers, silencers, or locus control regions),which can be located many kilobase pairs from the promoter. Second, several individual DNA elements are required for the regulated activity of a control regionthrough their concerted interaction with sequence-specific DNA-binding proteins. Third, no single DNA-binding protein appears to dictate the precise expression pattern of a given gene. In other words, none of the importanttranscription factors for a gene appear to be transcriptionally competent in precisely the same cell types as the target gene. Rather, the gene appears to be expressed whenthe many factors needed for the activity of the promoterand distant control regions are simultaneously competent(and when potential repressors are incompetent)..." @default.
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• W2027454940 date "1999-01-01" @default.
• W2027454940 modified "2023-10-18" @default.
• W2027454940 title "Mechanisms of Transcriptional Regulation in Lymphocyte Progenitors: Insight from an Analysis of the Terminal Transferase Promoter" @default.
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• W2027454940 doi "https://doi.org/10.1101/sqb.1999.64.87" @default.
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