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- W2027463984 abstract "Three proteins expressed early in the replicative cycle of polyomavirus also play an essential role during virus-mediated tumorigenesis. One of the proteins, middle-T antigen, has been shown to bind cellular proteins involved in cell signalling such as c-Src, phosphatase 2A, phosphatidylinositol 3-kinase and SHC. Association of middle-T antigen with cellular membranes has been shown to be essential for middle-T-mediated cell transformation. A mutant virus encoding a truncated form of middle-T lacking a carboxy-terminal hydrophobic sequence mediating membrane association is not oncogenic. This mutant middle-T still binds phosphatase 2A through amino-terminal sequences common to small-and middle-T and is localized in the nucleus, although the protein does not contain a classical nuclear targeting sequence. Mutations introduced into the amino-terminal domain affecting the ability of truncated middle-T to bind phosphatase 2A prevented accumulation of the protein in the nucleus and led to localization in the cytoplasm. This suggests that nuclear localization of truncated middle-T may be a consequence of binding to phosphatase 2A." @default.
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- W2027463984 date "1996-01-01" @default.
- W2027463984 modified "2023-09-26" @default.
- W2027463984 title "Polyomavirus middle-T antigen lacking a membrane anchor sequence accumulates in the nucleus" @default.
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- W2027463984 doi "https://doi.org/10.1099/0022-1317-77-1-17" @default.
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