Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027469265> ?p ?o ?g. }
- W2027469265 endingPage "1440" @default.
- W2027469265 startingPage "1433" @default.
- W2027469265 abstract "No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 May 2001REDUCING MUCUS PRODUCTION AFTER URINARY RECONSTRUCTION: A PROSPECTIVE RANDOMIZED TRIALis corrected byERRATA J. N’DOW, C.N. ROBSON, J.N.S. MATTHEWS, D.E. NEAL, and J.P. PEARSON J. N’DOWJ. N’DOW More articles by this author , C.N. ROBSONC.N. ROBSON More articles by this author , J.N.S. MATTHEWSJ.N.S. MATTHEWS More articles by this author , D.E. NEALD.E. NEAL More articles by this author , and J.P. PEARSONJ.P. PEARSON More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66323-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: After transposition into the urinary tract, intestinal segments continue to produce mucus. We determine the effectiveness of muco-regulatory drugs, including N-acetylcysteine, aspirin and ranitidine, in reducing mucus secretion and urine viscosity in patients with transposed segments. Materials and Methods: Our trial was a prospective randomized, double-blind placebo controlled crossover study involving 12 patients who underwent ileal conduit and 31 who underwent bladder reconstruction. Each treatment lasted 3 weeks with a 2-week washout. Pretreatment and posttreatment 24-hour urine samples were analyzed for mucin and viscosity after papain digestion, sodium dodecyl sulfate-polyacrylamide gel electrophoresis and periodic acid-Schiff assay. A disease specific questionnaire and SF-36 quality of life survey were completed. Results: According to the questionnaire, mucus production did not decrease with time in 67% of patients. Mucin comprised 3% of the total nondialyzable material in urine (65 mg./24-hour for ileal conduit and 60 mg./24-hour for bladder reconstruction). Analysis of questionnaires and laboratory results failed to demonstrate any benefit of taking muco-regulatory agents compared with placebo. Conclusions: The use of N-acetylcysteine, aspirin and ranitidine did not result in a reduction in mucin production, urine viscosity or improvement in quality of life. References 1 : Secreto-motor function of intestinal segments used in lower urinary tract reconstruction.. Br J Urol1987; 60: 532. Google Scholar 2 : Bladder augmentation: experience with 129 children and young-adults.. J Urol1990; 144: 445. Abstract, Google Scholar 3 : Voiding pattern, urinary volume, composition and bacterial contamination in patients with urinary-diversion via a continent ileal reservoir. Br J Urol1989; 63: 619. Google Scholar 4 : Rupture of ileal neobladder due to urethral obstruction by mucous plug. J Urol1990; 144: 740. Link, Google Scholar 5 : A novel method for the visualization of the in situ mucus layer in rat and man. Clin Sci1998; 95: 97. Google Scholar 6 : Constituents of mucus and their separation.. Br Med Bull1978; 34: 17. Google Scholar 7 : Some non-mucin components of mucus and their possible biological roles.. Ciba Found Symp1984; 109: 121. Google Scholar 8 : Gastrointestinal mucus. In: Handbook of Physiology: The Gastrointestinal System III. Edited by . : American Physiological Society1989: 359. Google Scholar 9 : The action of proteolytic enzymes on the glycoprotein from pig gastric mucus.. Biochem J1977; 163: 363. Google Scholar 10 : Modification of the rheological properties of mucus by drugs.. Adv Exp Med Biol1982; 144: 75. Google Scholar 11 : Acute ureteral obstruction secondary to mucoid impaction in supravesical diversion: treatment with NAC. Urology1974; 3: 486. Google Scholar 12 : Acetylcysteine for urinary-tract mucolysis.. J Urol1988; 139: 353. Abstract, Google Scholar 13 : The dissolution of urinary mucus after cystoplasty.. Br J Urol1989; 63: 372. Google Scholar 14 : Cranberry juice and the mucus production in the urine of entero-uroplasties. J Urol1989; 141: 305A. abstract 542. Google Scholar 15 : The use of urea for dissolution of urinary mucus in urinary tract reconstruction.. J Urol1994; 151: 1036. Abstract, Google Scholar 16 : The effect of ranitidine on urine mucus concentration in patients with enterocystoplasty. Br J Urol1992; 70: 30. Google Scholar 17 : Acetylcysteine: a drug that is much more than a mucokinetic.. Biomed Pharmacother1988; 42: 513. Google Scholar 18 : Inhibition of human gallbladder mucus synthesis in patients undergoing cholecystectomy. Gut1992; 33: 1113. Google Scholar 19 : Mucus glycoprotein-biosynthesis in the human gallbladder: inhibition by aspirin.. Gut1992; 33: 1109. Google Scholar 20 : Aspirin changes the secretion rate and amino acid composition of human small intestinal mucin in subjects with ileal conduits. Glycoconj J1996; 13: 781. Google Scholar 21 : Design a questionnaire.. Br Med J1993; 307: 1264. Google Scholar 22 : An application of hierarchical kappa-type statistics in the of majority agreement among multiple observers.. Biometrics1977; 33: 363. Google Scholar 23 : The measurement of observer agreement for categorical data.. Biometrics1977; 33: 159. Google Scholar 24 : Is the SF-36 a valid measure of change in population health? Results from the Whitehall II study. Br Med J1997; 315: 1273. Google Scholar 25 : Isolation and characterization of the native glycoprotein from pig small-intestinal mucus.. Biochem J1981; 195: 267. Google Scholar 26 : Does normal urine contain mucin?. Br J Urol1997; 80: 161. Google Scholar 27 : Patients with ulcerative colitis have reduced mucin polymer content in the adherent colonic mucus gel. Biochem Soc Trans1995; 23: S104. Google Scholar 28 : Characterization of gastric mucoproteins isolated by equilibrium density-gradient centrifugation in caesium chloride.. Biochem J1974; 141: 633. Google Scholar 29 : Augmentation and substitution enterocystoplasty.. J Urol1986; 135: 215. Abstract, Google Scholar 30 : Metabolic longterm follow-up of the ileal neobladder. Eur Urol1993; 24: 197. Google Scholar 31 : Metabolic complications of cystoplasty.. Br J Urol1989; 63: 165. Google Scholar 32 : Nutritional consequences of bowel segments in the lower urinary tract. J Urol1989; 142: 509. Link, Google Scholar 33 : A colorimetric assay for glycoproteins based on the periodic acid/Schiff stain.. Biochem Soc Trans1978; 6: 607. Google Scholar 34 : Model systems for the evaluation of mucolytic drugs: acetylcysteine and S-carboxymethylcysteine. J Pharm Pharmacol1990; 42: 73. Google Scholar From the Departments of Surgery, Physiological Sciences and Statistics, University of Newcastle upon Tyne, Newcastle upon Tyne, England© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byZehnder P, Dhar N, Thurairaja R, Ochsner K and Studer U (2009) Effect of Urinary Tract Infection on Reservoir Function in Patients With Ileal Bladder SubstituteJournal of Urology, VOL. 181, NO. 6, (2545-2549), Online publication date: 1-Jun-2009.NABI G, YONG S, ONG E, McPHERSON G, GRANT A and N’DOW J (2018) IS ORTHOTOPIC BLADDER REPLACEMENT THE NEW GOLD STANDARD? EVIDENCE FROM A SYSTEMATIC REVIEWJournal of Urology, VOL. 174, NO. 1, (21-28), Online publication date: 1-Jul-2005.N′DOW J, JORDAN N, ROBSON C, NEAL D and PEARSON J (2018) THE BLADDER DOES NOT APPEAR TO HAVE A DYNAMIC SECRETED CONTINUOUS MUCOUS GEL LAYERJournal of Urology, VOL. 173, NO. 6, (2025-2031), Online publication date: 1-Jun-2005.KEEGAN S, GRAHAM C, NEAL D, BLUM-OEHLER G, N’DOW J, PEARSON J and GALLY D (2018) Characterization of Escherichia Coli Strains Causing Urinary Tract Infections in Patients With Transposed Intestinal SegmentsJournal of Urology, VOL. 169, NO. 6, (2382-2387), Online publication date: 1-Jun-2003.Related articlesJournal of Urology9 Nov 2018ERRATA Volume 165Issue 5May 2001Page: 1433-1440 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.KeywordsexpectorantsranitidinemucusaspirinacetylcysteineMetricsAuthor Information J. N’DOW More articles by this author C.N. ROBSON More articles by this author J.N.S. MATTHEWS More articles by this author D.E. NEAL More articles by this author J.P. PEARSON More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
- W2027469265 created "2016-06-24" @default.
- W2027469265 creator A5013627063 @default.
- W2027469265 creator A5030899252 @default.
- W2027469265 creator A5040094511 @default.
- W2027469265 creator A5070474989 @default.
- W2027469265 creator A5090899482 @default.
- W2027469265 date "2001-05-01" @default.
- W2027469265 modified "2023-10-02" @default.
- W2027469265 title "REDUCING MUCUS PRODUCTION AFTER URINARY RECONSTRUCTION: A PROSPECTIVE RANDOMIZED TRIAL" @default.
- W2027469265 cites W123492418 @default.
- W2027469265 cites W1489396407 @default.
- W2027469265 cites W159235180 @default.
- W2027469265 cites W168201121 @default.
- W2027469265 cites W1801703436 @default.
- W2027469265 cites W1969283069 @default.
- W2027469265 cites W1971240757 @default.
- W2027469265 cites W1978910276 @default.
- W2027469265 cites W2001146069 @default.
- W2027469265 cites W2007054079 @default.
- W2027469265 cites W2048214780 @default.
- W2027469265 cites W2072077157 @default.
- W2027469265 cites W2106939052 @default.
- W2027469265 cites W2107337746 @default.
- W2027469265 cites W2119416072 @default.
- W2027469265 cites W2127898783 @default.
- W2027469265 cites W2164777277 @default.
- W2027469265 cites W2188749728 @default.
- W2027469265 cites W2334979906 @default.
- W2027469265 cites W2394855442 @default.
- W2027469265 cites W2398633287 @default.
- W2027469265 cites W2402464922 @default.
- W2027469265 cites W2416944168 @default.
- W2027469265 cites W2443472727 @default.
- W2027469265 cites W4253468528 @default.
- W2027469265 cites W4294214797 @default.
- W2027469265 cites W53929440 @default.
- W2027469265 cites W88725230 @default.
- W2027469265 cites W91371213 @default.
- W2027469265 doi "https://doi.org/10.1016/s0022-5347(05)66323-9" @default.
- W2027469265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11342892" @default.
- W2027469265 hasPublicationYear "2001" @default.
- W2027469265 type Work @default.
- W2027469265 sameAs 2027469265 @default.
- W2027469265 citedByCount "43" @default.
- W2027469265 countsByYear W20274692652012 @default.
- W2027469265 countsByYear W20274692652014 @default.
- W2027469265 countsByYear W20274692652016 @default.
- W2027469265 countsByYear W20274692652017 @default.
- W2027469265 countsByYear W20274692652018 @default.
- W2027469265 countsByYear W20274692652019 @default.
- W2027469265 countsByYear W20274692652020 @default.
- W2027469265 countsByYear W20274692652021 @default.
- W2027469265 countsByYear W20274692652022 @default.
- W2027469265 countsByYear W20274692652023 @default.
- W2027469265 crossrefType "journal-article" @default.
- W2027469265 hasAuthorship W2027469265A5013627063 @default.
- W2027469265 hasAuthorship W2027469265A5030899252 @default.
- W2027469265 hasAuthorship W2027469265A5040094511 @default.
- W2027469265 hasAuthorship W2027469265A5070474989 @default.
- W2027469265 hasAuthorship W2027469265A5090899482 @default.
- W2027469265 hasConcept C126322002 @default.
- W2027469265 hasConcept C126894567 @default.
- W2027469265 hasConcept C168563851 @default.
- W2027469265 hasConcept C177713679 @default.
- W2027469265 hasConcept C18903297 @default.
- W2027469265 hasConcept C2777312293 @default.
- W2027469265 hasConcept C71924100 @default.
- W2027469265 hasConcept C77411442 @default.
- W2027469265 hasConcept C86803240 @default.
- W2027469265 hasConceptScore W2027469265C126322002 @default.
- W2027469265 hasConceptScore W2027469265C126894567 @default.
- W2027469265 hasConceptScore W2027469265C168563851 @default.
- W2027469265 hasConceptScore W2027469265C177713679 @default.
- W2027469265 hasConceptScore W2027469265C18903297 @default.
- W2027469265 hasConceptScore W2027469265C2777312293 @default.
- W2027469265 hasConceptScore W2027469265C71924100 @default.
- W2027469265 hasConceptScore W2027469265C77411442 @default.
- W2027469265 hasConceptScore W2027469265C86803240 @default.
- W2027469265 hasIssue "5" @default.
- W2027469265 hasLocation W20274692651 @default.
- W2027469265 hasLocation W20274692652 @default.
- W2027469265 hasOpenAccess W2027469265 @default.
- W2027469265 hasPrimaryLocation W20274692651 @default.
- W2027469265 hasRelatedWork W168201121 @default.
- W2027469265 hasRelatedWork W2392413698 @default.
- W2027469265 hasRelatedWork W2517659937 @default.
- W2027469265 hasRelatedWork W3159250744 @default.
- W2027469265 hasRelatedWork W4235671009 @default.
- W2027469265 hasRelatedWork W4256514411 @default.
- W2027469265 hasRelatedWork W4288392727 @default.
- W2027469265 hasRelatedWork W4292236216 @default.
- W2027469265 hasRelatedWork W2083697902 @default.
- W2027469265 hasRelatedWork W2118673085 @default.
- W2027469265 hasVolume "165" @default.
- W2027469265 isParatext "false" @default.
- W2027469265 isRetracted "false" @default.
- W2027469265 magId "2027469265" @default.