FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027474410> ?p ?o ?g. }

• W2027474410 endingPage "e1003051" @default.
• W2027474410 startingPage "e1003051" @default.
• W2027474410 abstract "The expansion of CAG/CTG repeats is responsible for many diseases, including Huntington's disease (HD) and myotonic dystrophy 1. CAG/CTG expansions are unstable in selective somatic tissues, which accelerates disease progression. The mechanisms underlying repeat instability are complex, and it remains unclear whether chromatin structure and/or transcription contribute to somatic CAG/CTG instability in vivo. To address these issues, we investigated the relationship between CAG instability, chromatin structure, and transcription at the HD locus using the R6/1 and R6/2 HD transgenic mouse lines. These mice express a similar transgene, albeit integrated at a different site, and recapitulate HD tissue-specific instability. We show that instability rates are increased in R6/2 tissues as compared to R6/1 matched-samples. High transgene expression levels and chromatin accessibility correlated with the increased CAG instability of R6/2 mice. Transgene mRNA and H3K4 trimethylation at the HD locus were increased, whereas H3K9 dimethylation was reduced in R6/2 tissues relative to R6/1 matched-tissues. However, the levels of transgene expression and these specific histone marks were similar in the striatum and cerebellum, two tissues showing very different CAG instability levels, irrespective of mouse line. Interestingly, the levels of elongating RNA Pol II at the HD locus, but not the initiating form of RNA Pol II, were tissue-specific and correlated with CAG instability levels. Similarly, H3K36 trimethylation, a mark associated with transcription elongation, was specifically increased at the HD locus in the striatum and not in the cerebellum. Together, our data support the view that transcription modulates somatic CAG instability in vivo. More specifically, our results suggest for the first time that transcription elongation is regulated in a tissue-dependent manner, contributing to tissue-selective CAG instability." @default.
• W2027474410 created "2016-06-24" @default.
• W2027474410 creator A5004447443 @default.
• W2027474410 creator A5008032977 @default.
• W2027474410 creator A5016814512 @default.
• W2027474410 creator A5033644051 @default.
• W2027474410 creator A5079663586 @default.
• W2027474410 creator A5083348187 @default.
• W2027474410 date "2012-11-29" @default.
• W2027474410 modified "2023-10-01" @default.
• W2027474410 title "Transcription Elongation and Tissue-Specific Somatic CAG Instability" @default.
• W2027474410 cites W1522901791 @default.
• W2027474410 cites W1653978584 @default.
• W2027474410 cites W1798173089 @default.
• W2027474410 cites W1964096828 @default.
• W2027474410 cites W1971471193 @default.
• W2027474410 cites W1975302496 @default.
• W2027474410 cites W1977377806 @default.
• W2027474410 cites W1978740993 @default.
• W2027474410 cites W1986594553 @default.
• W2027474410 cites W1989365498 @default.
• W2027474410 cites W1992927069 @default.
• W2027474410 cites W1994285647 @default.
• W2027474410 cites W1995109357 @default.
• W2027474410 cites W1996425563 @default.
• W2027474410 cites W2006764478 @default.
• W2027474410 cites W2009696013 @default.
• W2027474410 cites W2015416439 @default.
• W2027474410 cites W2015557667 @default.
• W2027474410 cites W2019378882 @default.
• W2027474410 cites W2023524368 @default.
• W2027474410 cites W2024357446 @default.
• W2027474410 cites W2025327704 @default.
• W2027474410 cites W2026802661 @default.
• W2027474410 cites W2034823585 @default.
• W2027474410 cites W2037606715 @default.
• W2027474410 cites W2046082575 @default.
• W2027474410 cites W2050476079 @default.
• W2027474410 cites W2051139983 @default.
• W2027474410 cites W2051234541 @default.
• W2027474410 cites W2062682951 @default.
• W2027474410 cites W2064563306 @default.
• W2027474410 cites W2065888384 @default.
• W2027474410 cites W2071254988 @default.
• W2027474410 cites W2072853045 @default.
• W2027474410 cites W2072898686 @default.
• W2027474410 cites W2073315036 @default.
• W2027474410 cites W2082929666 @default.
• W2027474410 cites W2085617522 @default.
• W2027474410 cites W2085853194 @default.
• W2027474410 cites W2091198609 @default.
• W2027474410 cites W2091718095 @default.
• W2027474410 cites W2092574488 @default.
• W2027474410 cites W2093443640 @default.
• W2027474410 cites W2096083625 @default.
• W2027474410 cites W2099564858 @default.
• W2027474410 cites W2100591042 @default.
• W2027474410 cites W2106539538 @default.
• W2027474410 cites W2111714867 @default.
• W2027474410 cites W2112888760 @default.
• W2027474410 cites W2113189443 @default.
• W2027474410 cites W2113629413 @default.
• W2027474410 cites W2117099883 @default.
• W2027474410 cites W2124161762 @default.
• W2027474410 cites W2124651100 @default.
• W2027474410 cites W2125442413 @default.
• W2027474410 cites W2126149307 @default.
• W2027474410 cites W2128605862 @default.
• W2027474410 cites W2129448601 @default.
• W2027474410 cites W2132613957 @default.
• W2027474410 cites W2133938268 @default.
• W2027474410 cites W2135199520 @default.
• W2027474410 cites W2136082132 @default.
• W2027474410 cites W2136218435 @default.
• W2027474410 cites W2136243961 @default.
• W2027474410 cites W2140485864 @default.
• W2027474410 cites W2148649115 @default.
• W2027474410 cites W2154109129 @default.
• W2027474410 cites W2155706737 @default.
• W2027474410 cites W2157462132 @default.
• W2027474410 cites W2163987346 @default.
• W2027474410 doi "https://doi.org/10.1371/journal.pgen.1003051" @default.
• W2027474410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3510035" @default.
• W2027474410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23209427" @default.
• W2027474410 hasPublicationYear "2012" @default.
• W2027474410 type Work @default.
• W2027474410 sameAs 2027474410 @default.
• W2027474410 citedByCount "55" @default.
• W2027474410 countsByYear W20274744102013 @default.
• W2027474410 countsByYear W20274744102014 @default.
• W2027474410 countsByYear W20274744102015 @default.
• W2027474410 countsByYear W20274744102016 @default.
• W2027474410 countsByYear W20274744102017 @default.
• W2027474410 countsByYear W20274744102018 @default.
• W2027474410 countsByYear W20274744102019 @default.
• W2027474410 countsByYear W20274744102020 @default.
• W2027474410 countsByYear W20274744102021 @default.
• W2027474410 countsByYear W20274744102022 @default.

• next