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- W2027481270 abstract "Abstract Rationale Total IgE levels in humans show a strong tracking tendency from birth via unknown mechanisms. While in-vitro studies have shown the role of individual cytokines in regulating IgE production, little is known about the association of cytokine production and IgE levels in vivo. Methods Blood was obtained from 3 groups of subjects participating in the Tucson Infant Immune Study: children at birth and at 3 months of age; fathers; mothers pre- and post-delivery. IFN gamma, IL-4, IL-5, IL-13, and IL-10 were measured in supernatants of mitogen stimulated PBMCs. Percent eosinophils was determined in peripheral blood. Log normally distributed total serum IgE were examined for relation to cytokine production using simple regression, multiple regression with cytokines only, and finally a multiple regression model including other known predictors of IgE levels. Results IL-5 was associated with total serum IgE in children at 3 months but not at birth after adjusting for other predictors (N=122; slope 0.127, p=0.026). This association was even stronger in fathers (N=165; slope 0.144, p=0.024) and in mothers, both during pregnancy (N=218; slope 0.155, p=0.003) and after delivery (N=143; slope 0.253, p=0.009). IL-5 remained the only cytokine showing a relation to IgE which was independent of eosinophil levels and of other known predictors of IgE. Conclusions This study indicates that IL-5 production is associated with total IgE levels in vivo, independent of its known effects on eosinophil longevity." @default.
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- W2027481270 date "2004-02-01" @default.
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- W2027481270 title "In vivo association of cytokine production and IgE levels in infants and adults*1" @default.
- W2027481270 doi "https://doi.org/10.1016/j.jaci.2003.12.294" @default.
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