FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027487323> ?p ?o ?g. }

• W2027487323 endingPage "27911" @default.
• W2027487323 startingPage "27898" @default.
• W2027487323 abstract "Mediator, a large multisubunit protein complex, plays a pivotal role in gene transcription by linking gene-specific transcription factors with the preinitiation complex and RNA polymerase II. In the liver, the key subunit of the Mediator complex, Med1, interacts with several nuclear receptors and transcription factors to direct gene-specific transcription. Conditional knock-out of Med1 in the liver showed that hepatocytes lacking Med1 did not regenerate following either partial hepatectomy or treatment with certain nuclear receptor activators and failed to give rise to tumors when challenged with carcinogens. We now report that the adenovirally driven overexpression of Med1 in mouse liver stimulates hepatocyte DNA synthesis with enhanced expression of DNA replication, cell cycle control, and liver-specific genes, indicating that Med1 alone is necessary and sufficient for liver cell proliferation. Importantly, we demonstrate that AMP-activated protein kinase (AMPK), an important cellular energy sensor, interacts with, and directly phosphorylates, Med1 in vitro at serine 656, serine 756, and serine 796. AMPK also phosphorylates Med1 in vivo in mouse liver and in cultured primary hepatocytes and HEK293 and HeLa cells. In addition, we demonstrate that PPARα activators increase AMPK-mediated Med1 phosphorylation in vivo. Inhibition of AMPK by compound C decreased hepatocyte proliferation induced by Med1 and also by the PPARα activators fenofibrate and Wy-14,643. Co-treatment with compound C attenuated PPARα activator-inducible fatty acid β-oxidation in liver. Our results suggest that Med1 phosphorylation by its association with AMPK regulates liver cell proliferation and fatty acid oxidation, most likely as a downstream effector of PPARα and AMPK." @default.
• W2027487323 created "2016-06-24" @default.
• W2027487323 creator A5000296373 @default.
• W2027487323 creator A5005326970 @default.
• W2027487323 creator A5008199212 @default.
• W2027487323 creator A5017034809 @default.
• W2027487323 creator A5023821843 @default.
• W2027487323 creator A5034754078 @default.
• W2027487323 creator A5053984606 @default.
• W2027487323 creator A5057095504 @default.
• W2027487323 creator A5058627249 @default.
• W2027487323 creator A5070827775 @default.
• W2027487323 creator A5073932699 @default.
• W2027487323 creator A5081839578 @default.
• W2027487323 creator A5089191106 @default.
• W2027487323 date "2013-09-01" @default.
• W2027487323 modified "2023-10-16" @default.
• W2027487323 title "The Med1 Subunit of the Mediator Complex Induces Liver Cell Proliferation and Is Phosphorylated by AMP Kinase" @default.
• W2027487323 cites W1553011847 @default.
• W2027487323 cites W1593089530 @default.
• W2027487323 cites W1924431080 @default.
• W2027487323 cites W1973622869 @default.
• W2027487323 cites W1974658675 @default.
• W2027487323 cites W1979267620 @default.
• W2027487323 cites W1982085282 @default.
• W2027487323 cites W1985338761 @default.
• W2027487323 cites W1988453853 @default.
• W2027487323 cites W1998420703 @default.
• W2027487323 cites W2000950973 @default.
• W2027487323 cites W2001568034 @default.
• W2027487323 cites W2001761213 @default.
• W2027487323 cites W2002024664 @default.
• W2027487323 cites W2008698762 @default.
• W2027487323 cites W2010238890 @default.
• W2027487323 cites W2011574523 @default.
• W2027487323 cites W2011908601 @default.
• W2027487323 cites W2015721847 @default.
• W2027487323 cites W2016752484 @default.
• W2027487323 cites W2020466484 @default.
• W2027487323 cites W2020600607 @default.
• W2027487323 cites W2022395399 @default.
• W2027487323 cites W2028716770 @default.
• W2027487323 cites W2035651268 @default.
• W2027487323 cites W2038116978 @default.
• W2027487323 cites W2041066379 @default.
• W2027487323 cites W2041390597 @default.
• W2027487323 cites W2042646346 @default.
• W2027487323 cites W2045393705 @default.
• W2027487323 cites W2046195617 @default.
• W2027487323 cites W2048217643 @default.
• W2027487323 cites W2056165615 @default.
• W2027487323 cites W2060468957 @default.
• W2027487323 cites W2064808629 @default.
• W2027487323 cites W2067553189 @default.
• W2027487323 cites W2067636697 @default.
• W2027487323 cites W2073514337 @default.
• W2027487323 cites W2077645437 @default.
• W2027487323 cites W2079551052 @default.
• W2027487323 cites W2081920342 @default.
• W2027487323 cites W2081934175 @default.
• W2027487323 cites W2085792867 @default.
• W2027487323 cites W2088355841 @default.
• W2027487323 cites W2092052707 @default.
• W2027487323 cites W2104492370 @default.
• W2027487323 cites W2105897677 @default.
• W2027487323 cites W2107752042 @default.
• W2027487323 cites W2109757092 @default.
• W2027487323 cites W2118578251 @default.
• W2027487323 cites W2119274218 @default.
• W2027487323 cites W2121914083 @default.
• W2027487323 cites W2124403328 @default.
• W2027487323 cites W2125806831 @default.
• W2027487323 cites W2126639455 @default.
• W2027487323 cites W2133088581 @default.
• W2027487323 cites W2136596508 @default.
• W2027487323 cites W2137199913 @default.
• W2027487323 cites W2138226825 @default.
• W2027487323 cites W2141616120 @default.
• W2027487323 cites W2148177611 @default.
• W2027487323 cites W2149920358 @default.
• W2027487323 cites W2157425241 @default.
• W2027487323 cites W2158268923 @default.
• W2027487323 cites W2168661333 @default.
• W2027487323 cites W28865656 @default.
• W2027487323 cites W4211173486 @default.
• W2027487323 doi "https://doi.org/10.1074/jbc.m113.486696" @default.
• W2027487323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3784705" @default.
• W2027487323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23943624" @default.
• W2027487323 hasPublicationYear "2013" @default.
• W2027487323 type Work @default.
• W2027487323 sameAs 2027487323 @default.
• W2027487323 citedByCount "19" @default.
• W2027487323 countsByYear W20274873232014 @default.
• W2027487323 countsByYear W20274873232015 @default.
• W2027487323 countsByYear W20274873232016 @default.
• W2027487323 countsByYear W20274873232018 @default.
• W2027487323 countsByYear W20274873232019 @default.
• W2027487323 countsByYear W20274873232021 @default.

• next