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• W2027492024 abstract "The molecular and cellular events involved in cancer progression and metastasis remain much less well-defined than those involved in oncogenesis, despite the fact that cell metastasis is the major factor in cancer mortality. Thus, the discovery that the expression of a protein tyrosine phosphatase, protein of regenerating liver-3 (PRL-3), is upregulated in colon cancer metastases provided an exciting indication that the altered regulation of specific protein tyrosine phosphorylation events and signaling pathways might characterize these metastatic cells and/or be key in promoting the tumor-to-metastasis transition in this, and perhaps other, cancers of epithelial origin. However, the cellular substrate(s) of PRL-3 has not been identified, and little is known of PRL-3-mediated cellular signaling pathways. This review illustrates the significance of PRL-3 in promoting metastasis and the importance of determining the endogenous role of PRL-3." @default.
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• W2027492024 date "2007-01-01" @default.
• W2027492024 modified "2023-09-27" @default.
• W2027492024 title "PRL-3: A Metastasis-Associated Phosphatase in Search of a Function" @default.
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• W2027492024 doi "https://doi.org/10.1159/000101324" @default.
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