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• W2027492033 endingPage "235" @default.
• W2027492033 startingPage "225" @default.
• W2027492033 abstract "Inhalation of salmeterol xinafoate (SX) and fluticasone propionate (FP) from a combination product is reported to produce superior clinical outcomes in comparison to the concurrent administration of 'similar' doses via separate single-active inhalers. For bioequivalence determination across different products, emphasis is currently placed on the assessment of drug deposition within inertial impactors on a 'stage-by-stage' basis as stipulated in a recent European Medicines Agency guidance. The aim of this study was to compare the stage-by-stage deposition of drugs aerosolised from the single-active Accuhaler® products Serevent® (SX) and Flixotide® (FP) with the SX-FP combination product Seretide® Accuhaler® in vitro. Drug deposition on a stage-by-stage basis was assessed using the next generation impactor (NGI). Significant differences in drug deposition profiles were obtained following aerosolisation from the single-active versus combination products. The concurrent administration of the two single-active products: Serevent® and Flixotide® Accuhaler® may not be bioequivalent to inhalation of the combination product Seretide® Accuhaler®. The observed differences may have resulted from different characteristics of the active pharmaceutical ingredient (APIs) and the carrier alpha-lactose monohydrate between the single-active and combination inhalers and/or a change in the drug-carrier inter-particulate interaction as a consequence of the presence of a second active." @default.
• W2027492033 created "2016-06-24" @default.
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• W2027492033 date "2011-07-01" @default.
• W2027492033 modified "2023-09-27" @default.
• W2027492033 title "The ‘stage-by-stage’ deposition of drugs from commercial single-active and combination dry powder inhaler formulations" @default.
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• W2027492033 doi "https://doi.org/10.1016/j.ejps.2011.04.014" @default.
• W2027492033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21549837" @default.
• W2027492033 hasPublicationYear "2011" @default.
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