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- W2027493756 abstract "N-(benzyloxycarbonyl)-L-aspartyl-L-phenylalanine methyl ester (ZAPM), an aspartame precursor, was synthesized enzymatically from N-(benzyloxycarbonyl)-L-aspartic acid (ZA) and L-phenylalanine methyl ester (PM) using a biphasic reaction system. Measurement of the partition coefficient in an aqueous/alcohol system showed that, 1-hexanol and 1-heptanol were proper solvents for the system. The membrane phase separation could be performed using a hydrophobic membrane, and 1-hexanol gave higher flux than 1-heptanol. Integration of the membrane phase separation into the biphasic enzyme reaction system was realized by the continuous stable ZAPM production." @default.
- W2027493756 created "2016-06-24" @default.
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- W2027493756 date "2000-01-01" @default.
- W2027493756 modified "2023-10-17" @default.
- W2027493756 title "Application of membrane phase separation for enzymatic synthesis of aspartame precursor in biphasic reaction system" @default.
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- W2027493756 doi "https://doi.org/10.1016/s1369-703x(99)00037-6" @default.
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