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- W2027494665 abstract "Abnormal bone remodelling in the vicinity of tumor cells is a common, early feature of multiple myeloma, characterized by excessive bone resorption which is mediated by local soluble factors called osteoclast activating factors (OAF). Since interleukin-1 (IL-1) and tumor necrosis factors (TNF) are potent, synergistic OAF produced by cells of the B-cell lineage, the authors investigated the spontaneous secretion of these cytokines by 11 human myeloma cell lines (HMCL). No HMCL secreted either IL-1, the most powerful OAF, or contra IL-1. In contrast, all of the lymphoblastoid cell lines assayed produced significant IL-1 activity. Ten of the 11 HMCL secreted a significant TNF activity. This was completely eliminated by an anti-TNFβ monoclonal antibody but not affected by an anti-TNFα antiserum. The data from this study suggest that TNFβ is involved in myeloma bone resorption, but not IL-1, which is, however, known as one of the most potent OAF." @default.
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- W2027494665 date "1989-03-01" @default.
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- W2027494665 title "Spontaneous secretion of tumor necrosis factor-beta by human myeloma cell lines" @default.
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- W2027494665 doi "https://doi.org/10.1002/1097-0142(19890301)63:5<877::aid-cncr2820630514>3.0.co;2-6" @default.
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